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Slowing and loss of complexity in Alzheimer's EEG : two sides of the same coin?

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Slowing and loss of complexity in Alzheimer's EEG : two sides of the same coin?
นักวิจัย : Dauwels, Justin , Srinivasan, K. , Reddy, M. Ramasubba , Musha, Toshimitsu , Vialatte, François-Benoît , Latchoumane, Charles , Jeong, Jaeseung , Cichocki, Andrzej
คำค้น : DRNTU::Engineering::Electrical and electronic engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2554
อ้างอิง : Dauwels, J., Srinivasan, K., Reddy, M. R., Musha, T., Vialatte, F.-B., Latchoumane, C. et al. (2011). Slowing and loss of complexity in Alzheimer's EEG : two sides of the same coin? International journal of Alzheimer's disease, 2011, 539621-. , 2090-0252 , http://hdl.handle.net/10220/18352 , http://dx.doi.org/10.4061/2011/539621 , 163246
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : International journal of alzheimer's disease
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Medical studies have shown that EEG of Alzheimer's disease (AD) patients is “slower” (i.e., contains more low-frequency power) and is less complex compared to age-matched healthy subjects. The relation between those two phenomena has not yet been studied, and they are often silently assumed to be independent. In this paper, it is shown that both phenomena are strongly related. Strong correlation between slowing and loss of complexity is observed in two independent EEG datasets: (1) EEG of predementia patients (a.k.a. Mild Cognitive Impairment; MCI) and control subjects; (2) EEG of mild AD patients and control subjects. The two data sets are from different patients, different hospitals and obtained through different recording systems. The paper also investigates the potential of EEG slowing and loss of EEG complexity as indicators of AD onset. In particular, relative power and complexity measures are used as features to classify the MCI and MiAD patients versus age-matched control subjects. When combined with two synchrony measures (Granger causality and stochastic event synchrony), classification rates of 83% (MCI) and 98% (MiAD) are obtained. By including the compression ratios as features, slightly better classification rates are obtained than with relative power and synchrony measures alone.

บรรณานุกรม :
Dauwels, Justin , Srinivasan, K. , Reddy, M. Ramasubba , Musha, Toshimitsu , Vialatte, François-Benoît , Latchoumane, Charles , Jeong, Jaeseung , Cichocki, Andrzej . (2554). Slowing and loss of complexity in Alzheimer's EEG : two sides of the same coin?.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Dauwels, Justin , Srinivasan, K. , Reddy, M. Ramasubba , Musha, Toshimitsu , Vialatte, François-Benoît , Latchoumane, Charles , Jeong, Jaeseung , Cichocki, Andrzej . 2554. "Slowing and loss of complexity in Alzheimer's EEG : two sides of the same coin?".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Dauwels, Justin , Srinivasan, K. , Reddy, M. Ramasubba , Musha, Toshimitsu , Vialatte, François-Benoît , Latchoumane, Charles , Jeong, Jaeseung , Cichocki, Andrzej . "Slowing and loss of complexity in Alzheimer's EEG : two sides of the same coin?."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2554. Print.
Dauwels, Justin , Srinivasan, K. , Reddy, M. Ramasubba , Musha, Toshimitsu , Vialatte, François-Benoît , Latchoumane, Charles , Jeong, Jaeseung , Cichocki, Andrzej . Slowing and loss of complexity in Alzheimer's EEG : two sides of the same coin?. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2554.