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Biogenic tellurium nanorods as a novel antivirulence agent inhibiting pyoverdine production in Pseudomonas aeruginosa

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Biogenic tellurium nanorods as a novel antivirulence agent inhibiting pyoverdine production in Pseudomonas aeruginosa
นักวิจัย : Mohanty, Anee , Kathawala, Mustafa Hussain , Zhang, Jianhua , Chen, William Wei Ning , Loo, Joachim Say Chye , Kjelleberg, Staffan , Yang, Liang , Cao, Bin
คำค้น : DRNTU::Engineering::Chemical engineering::Biotechnology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Mohanty, A., Kathawala, M. H., Zhang, J., Chen, W. N. W., Loo, S. C. J., Kjelleberg, S., et al. (2013). Biogenic tellurium nanorods as a novel antivirulence agent inhibiting pyoverdine production in Pseudomonas aeruginosa . Biotechnology and Bioengineering, 111(5), 858–865. , 0006-3592 , http://hdl.handle.net/10220/17820 , http://dx.doi.org/10.1002/bit.25147
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Biotechnology and bioengineering
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

While antibiotic resistance in bacteria is rapidly increasing, the development of new antibiotics has decreased in recent years. Antivirulence drugs disarming rather than killing pathogens have been proposed to alleviate the problem of resistance inherent to existing biocidal antibiotics. Here, we report a nontoxic biogenic nanomaterial as a novel antivirulence agent to combat bacterial infections caused by Pseudomonas aeruginosa. We synthesized, in an environmentally benign fashion, tellurium nanorods (TeNRs) using the metal-reducing bacterium Shewanella oneidensis, and found that the biogenic TeNRs could effectively inhibit the production of pyoverdine, one of the most important virulence factors in P. aeruginosa. Our results suggest that amyloids and extracellular polysaccharides Pel and Psl are not involved in the interactions between P. aeruginosa and the biogenic TeNRs, while flagellar movement plays an important role in the cell-TeNRs interaction. We further showed that the TeNRs (up to 100 µg/ml) did not exhibit cytotoxicity to human bronchial epithelial cells and murine macrophages. Thus, biogenic TeNRs hold promise as a novel antivirulence agent against P. aeruginosa.

NRF (Natl Research Foundation, S’pore)

MOE (Min. of Education, S’pore)

บรรณานุกรม :
Mohanty, Anee , Kathawala, Mustafa Hussain , Zhang, Jianhua , Chen, William Wei Ning , Loo, Joachim Say Chye , Kjelleberg, Staffan , Yang, Liang , Cao, Bin . (2556). Biogenic tellurium nanorods as a novel antivirulence agent inhibiting pyoverdine production in Pseudomonas aeruginosa.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Mohanty, Anee , Kathawala, Mustafa Hussain , Zhang, Jianhua , Chen, William Wei Ning , Loo, Joachim Say Chye , Kjelleberg, Staffan , Yang, Liang , Cao, Bin . 2556. "Biogenic tellurium nanorods as a novel antivirulence agent inhibiting pyoverdine production in Pseudomonas aeruginosa".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Mohanty, Anee , Kathawala, Mustafa Hussain , Zhang, Jianhua , Chen, William Wei Ning , Loo, Joachim Say Chye , Kjelleberg, Staffan , Yang, Liang , Cao, Bin . "Biogenic tellurium nanorods as a novel antivirulence agent inhibiting pyoverdine production in Pseudomonas aeruginosa."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Mohanty, Anee , Kathawala, Mustafa Hussain , Zhang, Jianhua , Chen, William Wei Ning , Loo, Joachim Say Chye , Kjelleberg, Staffan , Yang, Liang , Cao, Bin . Biogenic tellurium nanorods as a novel antivirulence agent inhibiting pyoverdine production in Pseudomonas aeruginosa. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.