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Fabrication and drug release study of double-layered microparticles of various sizes

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Fabrication and drug release study of double-layered microparticles of various sizes
นักวิจัย : Lee, Wei Li , Seh, Yi Chuan , Widjaja, Effendi , Chong, Han Chung , Tan, Nguan Soon , Loo, Say Chye Joachim
คำค้น : DRNTU::Engineering::Materials::Biomaterials.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Lee, W. L., Seh, Y. C., Widjaja, E., Chong, H. C., Tan, N. S., & Loo, S. C. J. (2012). Fabrication and drug release study of double-layered microparticles of various sizes. Journal of pharmaceutical sciences, 101(8), 2787-2797. , 0022-3549 , http://hdl.handle.net/10220/17460 , http://dx.doi.org/10.1002/jps.23191
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of pharmaceutical sciences
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Double-layered microparticles, composed of poly(D,L-lactide-co-glycolide) (50:50) (PLGA) core and poly(L-lactide) (PLLA) shell, of controllable sizes ranging from several hundred microns to few microns were fabricated using a one-step solvent evaporation method. Metoclopramide monohydrochloride monohydrate (MCA), a hydrophilic drug, was selectively localized in the PLGA core. To achieve the double-layered particles of size approximately 2 µm, the process parameters were carefully manipulated to extend the phase separation time by increasing oil-to-water ratio and saturating the surrounding aqueous phase with solvent. Subsequently, the drug release profiles of the double-layered particles of various sizes were studied. Increased particle size resulted in faster degradation of polymers because of autocatalysis, accelerating the release rate of MCA. Interestingly, the effect of degradation rates, affected by particle sizes, on drug release was insignificant when the particle size was drastically reduced to 2-20 µm in the investigated double-layered particles. This understanding would provide critical insights into how the controllable formation and unique drug release profiles of double-layered particles of various sizes can be achieved.

บรรณานุกรม :
Lee, Wei Li , Seh, Yi Chuan , Widjaja, Effendi , Chong, Han Chung , Tan, Nguan Soon , Loo, Say Chye Joachim . (2555). Fabrication and drug release study of double-layered microparticles of various sizes.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Wei Li , Seh, Yi Chuan , Widjaja, Effendi , Chong, Han Chung , Tan, Nguan Soon , Loo, Say Chye Joachim . 2555. "Fabrication and drug release study of double-layered microparticles of various sizes".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Wei Li , Seh, Yi Chuan , Widjaja, Effendi , Chong, Han Chung , Tan, Nguan Soon , Loo, Say Chye Joachim . "Fabrication and drug release study of double-layered microparticles of various sizes."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Lee, Wei Li , Seh, Yi Chuan , Widjaja, Effendi , Chong, Han Chung , Tan, Nguan Soon , Loo, Say Chye Joachim . Fabrication and drug release study of double-layered microparticles of various sizes. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.