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Collagen–cellulose composite thin films that mimic soft-tissue and allow stem-cell orientation

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Collagen–cellulose composite thin films that mimic soft-tissue and allow stem-cell orientation
นักวิจัย : Steele, Terry W. J. , Huang, Charlotte Liwen , Nguyen, Evelyne , Sarig, Udi , Kumar, Saranya , Widjaja, Effendi , Loo, Say Chye Joachim , Machluf, Marcelle , Boey, Freddy Yin Chiang , Vukadinovic, Zlata , Hilfiker, Andreas , Venkatraman, Subbu S.
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Steele, T. W. J., Huang, C. L., Nguyen, E., Sarig, U., Kumar, S., Widjaja, E., et al. (2013). Collagen–cellulose composite thin films that mimic soft-tissue and allow stem-cell orientation. Journal of materials science : materials in medicine, 24(8), 2013-2027. , http://hdl.handle.net/10220/17502 , http://dx.doi.org/10.1007/s10856-013-4940-3
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of materials science : materials in medicine
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Mechanical properties of collagen films are less than ideal for biomaterial development towards musculoskeletal repair or cardiovascular applications. Herein, we present a collagen–cellulose composite film (CCCF) compared against swine small intestine submucosa in regards to mechanical properties, cell growth, and histological analysis. CCCF was additionally characterized by FE-SEM, NMR, mass spectrometry, and Raman Microscopy to elucidate its physical structure, collagen–cellulose composition, and structure activity relationships. Mechanical properties of the CCCF were tested in both wet and dry environments, with anisotropic stress–strain curves that mimicked soft-tissue. Mesenchymal stem cells, human umbilical vein endothelial cells, and human coronary artery smooth muscle cells were able to proliferate on the collagen films with specific cell orientation. Mesenchymal stem cells had a higher proliferation index and were able to infiltrate CCCF to a higher degree than small intestine submucosa. With the underlying biological properties, we present a collagen–cellulose composite film towards forthcoming biomaterial-related applications.

บรรณานุกรม :
Steele, Terry W. J. , Huang, Charlotte Liwen , Nguyen, Evelyne , Sarig, Udi , Kumar, Saranya , Widjaja, Effendi , Loo, Say Chye Joachim , Machluf, Marcelle , Boey, Freddy Yin Chiang , Vukadinovic, Zlata , Hilfiker, Andreas , Venkatraman, Subbu S. . (2556). Collagen–cellulose composite thin films that mimic soft-tissue and allow stem-cell orientation.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Steele, Terry W. J. , Huang, Charlotte Liwen , Nguyen, Evelyne , Sarig, Udi , Kumar, Saranya , Widjaja, Effendi , Loo, Say Chye Joachim , Machluf, Marcelle , Boey, Freddy Yin Chiang , Vukadinovic, Zlata , Hilfiker, Andreas , Venkatraman, Subbu S. . 2556. "Collagen–cellulose composite thin films that mimic soft-tissue and allow stem-cell orientation".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Steele, Terry W. J. , Huang, Charlotte Liwen , Nguyen, Evelyne , Sarig, Udi , Kumar, Saranya , Widjaja, Effendi , Loo, Say Chye Joachim , Machluf, Marcelle , Boey, Freddy Yin Chiang , Vukadinovic, Zlata , Hilfiker, Andreas , Venkatraman, Subbu S. . "Collagen–cellulose composite thin films that mimic soft-tissue and allow stem-cell orientation."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Steele, Terry W. J. , Huang, Charlotte Liwen , Nguyen, Evelyne , Sarig, Udi , Kumar, Saranya , Widjaja, Effendi , Loo, Say Chye Joachim , Machluf, Marcelle , Boey, Freddy Yin Chiang , Vukadinovic, Zlata , Hilfiker, Andreas , Venkatraman, Subbu S. . Collagen–cellulose composite thin films that mimic soft-tissue and allow stem-cell orientation. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.