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The development of silk fibroin scaffolds using an indirect rapid prototyping approach : morphological analysis and cell growth monitoring by spectral-domain optical coherence tomography

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : The development of silk fibroin scaffolds using an indirect rapid prototyping approach : morphological analysis and cell growth monitoring by spectral-domain optical coherence tomography
นักวิจัย : Liu, M. J. J. , Chou, Siaw Meng , Chua, C. K. , Tay, B. C. M. , Ng, B. K.
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2554
อ้างอิง : Liu, M. J. J., Chou, S. M., Chua, C. K., Tay, B. C. M., & Ng, B. K. (2013). The development of silk fibroin scaffolds using an indirect rapid prototyping approach: Morphological analysis and cell growth monitoring by spectral-domain optical coherence tomography. Medical Engineering & Physics, 35(2), 253-262. , 1350-4533 , http://hdl.handle.net/10220/17493 , http://dx.doi.org/10.1016/j.medengphy.2011.09.029
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Medical engineering & physics
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

To date, naturally derived biomaterials are rarely used in advanced tissue engineering (TE) methods despite their superior biocompatibility. This is because these native materials, which consist mainly of proteins and polysaccharides, do not possess the ability to withstand harsh processing conditions. Unlike synthetic polymers, natural materials degrade and decompose rapidly in the presence of chemical solvents and high temperature, respectively. Thus, the fabrication of tissue scaffolds using natural biomaterials is often carried out using conventional techniques, where the efficiency in mass transport of nutrients and removal of waste products within the construct is compromised. The present study identified silk fibroin (SF) protein as a suitable material for the application of rapid prototyping (RP) or additive manufacturing (AM) technology. Using the indirect RP method, via the use of a mould, SF tissue scaffolds with both macro- and micro-morphological features can be produced and qualitatively examined by spectral-domain optical coherence tomography (SD-OCT). The advanced imaging technique showed the ability to differentiate the cells and SF material by producing high contrasting images, therefore suggesting the method as a feasible alternative to the histological analysis of cell growth within tissue scaffolds.

บรรณานุกรม :
Liu, M. J. J. , Chou, Siaw Meng , Chua, C. K. , Tay, B. C. M. , Ng, B. K. . (2554). The development of silk fibroin scaffolds using an indirect rapid prototyping approach : morphological analysis and cell growth monitoring by spectral-domain optical coherence tomography.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liu, M. J. J. , Chou, Siaw Meng , Chua, C. K. , Tay, B. C. M. , Ng, B. K. . 2554. "The development of silk fibroin scaffolds using an indirect rapid prototyping approach : morphological analysis and cell growth monitoring by spectral-domain optical coherence tomography".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liu, M. J. J. , Chou, Siaw Meng , Chua, C. K. , Tay, B. C. M. , Ng, B. K. . "The development of silk fibroin scaffolds using an indirect rapid prototyping approach : morphological analysis and cell growth monitoring by spectral-domain optical coherence tomography."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2554. Print.
Liu, M. J. J. , Chou, Siaw Meng , Chua, C. K. , Tay, B. C. M. , Ng, B. K. . The development of silk fibroin scaffolds using an indirect rapid prototyping approach : morphological analysis and cell growth monitoring by spectral-domain optical coherence tomography. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2554.