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The intrinsic helical propensities of the helical fragments in prion protein under neutral and low pH conditions : a replica exchange molecular dynamics study

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : The intrinsic helical propensities of the helical fragments in prion protein under neutral and low pH conditions : a replica exchange molecular dynamics study
นักวิจัย : Lu, Xiaoliang , Zeng, Juan , Gao, Ya , Zhang, John Z. H. , Zhang, Dawei , Mei, Ye
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Lu, X., Zeng, J., Gao, Y., Zhang, J. Z. H., Zhang, D., & Mei, Y. (2013). The intrinsic helical propensities of the helical fragments in prion protein under neutral and low pH conditions: a replica exchange molecular dynamics study. Journal of Molecular Modeling, 19(11), 4897-4908. , http://hdl.handle.net/10220/17372 , http://dx.doi.org/10.1007/s00894-013-1985-7
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of molecular modeling
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Replica exchange molecular dynamics simulations in neutral and acidic aqueous solutions were employed to study the intrinsic helical propensities of three helices in both Syrian hamster (syPrP) and human (huPrP) prion proteins. The helical propensities of syPrP HA and huPrP HA are very high under both pH conditions, which implies that HA is barely involved in the helix-to-β transition. The SyPrP HB chain has a strong tendency to adopt an extended conformation, which is possibly involved in the mechanism of infectious prion diseases in Syrian hamster. HuPrP HC has more of a preference for the extended conformation than huPrP HA and huPrP HB do, which leads to the conjecture that it is more likely to be the source of β-rich structure for human prion protein. We also noticed that the presence of salt bridges is not correlated with helical propensity, indicating that salt bridges do not stabilize helices.

บรรณานุกรม :
Lu, Xiaoliang , Zeng, Juan , Gao, Ya , Zhang, John Z. H. , Zhang, Dawei , Mei, Ye . (2556). The intrinsic helical propensities of the helical fragments in prion protein under neutral and low pH conditions : a replica exchange molecular dynamics study.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lu, Xiaoliang , Zeng, Juan , Gao, Ya , Zhang, John Z. H. , Zhang, Dawei , Mei, Ye . 2556. "The intrinsic helical propensities of the helical fragments in prion protein under neutral and low pH conditions : a replica exchange molecular dynamics study".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lu, Xiaoliang , Zeng, Juan , Gao, Ya , Zhang, John Z. H. , Zhang, Dawei , Mei, Ye . "The intrinsic helical propensities of the helical fragments in prion protein under neutral and low pH conditions : a replica exchange molecular dynamics study."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Lu, Xiaoliang , Zeng, Juan , Gao, Ya , Zhang, John Z. H. , Zhang, Dawei , Mei, Ye . The intrinsic helical propensities of the helical fragments in prion protein under neutral and low pH conditions : a replica exchange molecular dynamics study. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.