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Tianma modulates blood vessel tonicity

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Tianma modulates blood vessel tonicity
นักวิจัย : Feng, Lin , Manavalan, Arulmani , Mishra, Manisha , Sze, Siu Kwan , Hu, Jiang-Miao , Heese, Klaus
คำค้น : DRNTU::Science::Biological sciences::Biochemistry
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Feng, L., Manavalan, A., Mishra, M., Sze, S. K., Hu, J. M., & Heese, K. (2012). Tianma modulates blood vessel tonicity. The open biochemistry journal, 6, 56-65. , 1874-091X , http://hdl.handle.net/10220/17534 , http://dx.doi.org/10.2174/1874091X01206010056
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : The open biochemistry journal
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Tianma is a traditional Chinese medicine (TCM) often used for the treatment of hypertension and heart diseases. To elucidate the function of tianma at the molecular level, we investigated the effect of tianma on vascular functions and aortic protein metabolism. We found that long-term treatment with tianma (~2.5g/kg/day for three months) in one-year-old rats could enhance acetylcholine (ACh)-induced vasorelaxation in endothelium-intact thoracic aortic rings against both KCl (80 mM)- and phenylephrine (PE)-induced contraction. By using the iTRAQ (isobaric tag for relative and absolute quantification) technique, we confirmed from the functional data at the proteome level that tianma treatment down-regulated the expressions of contractile proteins (e.g. Acta2) and other related structural proteins (e.g. desmin), and up-regulated the expressions of extracellular matrix (ECM) glycoproteins (e.g. Fbln5) and anti-thrombotic proteins (e.g. Anxa2) in aortic tissue. By inductive reasoning, tianma could perform its vasodilatory effect not only by inhibiting vascular smooth muscle contraction, but also by enhancing blood vessel elasticity and stabilizing the arterial structure. Thus, tianma might become a novel therapeutic herbal medicine for cardiovascular diseases by regulating the aortic proteome metabolism.

บรรณานุกรม :
Feng, Lin , Manavalan, Arulmani , Mishra, Manisha , Sze, Siu Kwan , Hu, Jiang-Miao , Heese, Klaus . (2555). Tianma modulates blood vessel tonicity.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Feng, Lin , Manavalan, Arulmani , Mishra, Manisha , Sze, Siu Kwan , Hu, Jiang-Miao , Heese, Klaus . 2555. "Tianma modulates blood vessel tonicity".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Feng, Lin , Manavalan, Arulmani , Mishra, Manisha , Sze, Siu Kwan , Hu, Jiang-Miao , Heese, Klaus . "Tianma modulates blood vessel tonicity."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Feng, Lin , Manavalan, Arulmani , Mishra, Manisha , Sze, Siu Kwan , Hu, Jiang-Miao , Heese, Klaus . Tianma modulates blood vessel tonicity. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.