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The effects of nanofiber topography on astrocyte behavior and gene silencing efficiency

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : The effects of nanofiber topography on astrocyte behavior and gene silencing efficiency
นักวิจัย : Cao, Haoqing , Marcy, Guillaume , Goh, Eyleen , Wang, Feng , Wang, Jun , Chew, Sing Yian
คำค้น : DRNTU::Engineering::Chemical engineering::Biochemical engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Cao, H., Marcy, G., Goh, E. L. K., Wang, F., Wang, J., & Chew, S. Y. (2012). The effects of nanofiber topography on astrocyte behavior and gene silencing efficiency. Macromolecular bioscience, 12(5), 666-674. , 1616-5195 , http://hdl.handle.net/10220/17309 , http://dx.doi.org/10.1002/mabi.201100436
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Macromolecular bioscience
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Astrocyte-nanofiber interactions are studied by culturing primary rat cortical astrocytes on poly[caprolactone-co-(ethyl ethylene phosphate)] electrospun nanofibers and solvent-cast films (two-dimensional control). The results indicate that nanofiber topography significantly suppresses astrocyte proliferation and enhances apoptosis, without altering cellular activation as compared to films. Moreover, nanofiber topography enhances gene-silencing efficiency in astrocytes. The results suggest that nanofibers may serve as potential substrates for nerve regeneration by suppressing astrocyte growth and may further facilitate the use of gene-silencing to enhance CNS regeneration.

บรรณานุกรม :
Cao, Haoqing , Marcy, Guillaume , Goh, Eyleen , Wang, Feng , Wang, Jun , Chew, Sing Yian . (2555). The effects of nanofiber topography on astrocyte behavior and gene silencing efficiency.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Cao, Haoqing , Marcy, Guillaume , Goh, Eyleen , Wang, Feng , Wang, Jun , Chew, Sing Yian . 2555. "The effects of nanofiber topography on astrocyte behavior and gene silencing efficiency".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Cao, Haoqing , Marcy, Guillaume , Goh, Eyleen , Wang, Feng , Wang, Jun , Chew, Sing Yian . "The effects of nanofiber topography on astrocyte behavior and gene silencing efficiency."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Cao, Haoqing , Marcy, Guillaume , Goh, Eyleen , Wang, Feng , Wang, Jun , Chew, Sing Yian . The effects of nanofiber topography on astrocyte behavior and gene silencing efficiency. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.