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Biomimicking polysaccharide nanofibers promote vascular phenotypes : a potential application for vascular tissue engineering

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Biomimicking polysaccharide nanofibers promote vascular phenotypes : a potential application for vascular tissue engineering
นักวิจัย : Shi, Liya , Aid, Rachida , Visage, Catherine Le , Chew, Sing Yian
คำค้น : DRNTU::Engineering::Bioengineering
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Shi, L., Aid, R., Visage, C. L., & Chew, S. Y. (2012). Biomimicking polysaccharide nanofibers promote vascular phenotypes : A potential application for vascular tissue engineering. Macromolecular bioscience, 12(3), 395-401. , 1616-5187 , http://hdl.handle.net/10220/17323 , http://dx.doi.org/10.1002/mabi.201100336
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Macromolecular bioscience
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The potential of electrospun pullulan/dextran (P/D) nanofibers (average diameter = 323 nm) for vascular tissue engineering applications is explored. The mechanical properties of the nanofibers are of the same order of magnitude as that of human arteries (Young's modulus ≈0.88 MPa; tensile strength ≈0.35 MPa). It is demonstrated that the nanofiber topography enables cell adhesion and that the endothelial phenotype is maintained on the nanofibers. Moreover, P/D nanofibers support a stable confluent monolayer of endothelial cells over 14 d. SMCs seeded on nanofibers display similar levels of alpha smooth muscle actin and a lower proliferation rate than cells on 2D cultures. The observations suggest that nanofibers promote a shift to a quiescent contractile phenotype in SMCs.

บรรณานุกรม :
Shi, Liya , Aid, Rachida , Visage, Catherine Le , Chew, Sing Yian . (2555). Biomimicking polysaccharide nanofibers promote vascular phenotypes : a potential application for vascular tissue engineering.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Shi, Liya , Aid, Rachida , Visage, Catherine Le , Chew, Sing Yian . 2555. "Biomimicking polysaccharide nanofibers promote vascular phenotypes : a potential application for vascular tissue engineering".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Shi, Liya , Aid, Rachida , Visage, Catherine Le , Chew, Sing Yian . "Biomimicking polysaccharide nanofibers promote vascular phenotypes : a potential application for vascular tissue engineering."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Shi, Liya , Aid, Rachida , Visage, Catherine Le , Chew, Sing Yian . Biomimicking polysaccharide nanofibers promote vascular phenotypes : a potential application for vascular tissue engineering. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.