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Matricellular proteins : a sticky affair with cancers

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Matricellular proteins : a sticky affair with cancers
นักวิจัย : Chong, Han Chung , Tan, Chek Kun , Huang, Royston-Luke , Tan, Nguan Soon
คำค้น : DRNTU::Science::Biological sciences.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Chong, H. C., Tan, C. K., Huang, R.-L., & Tan, N. S. (2012). Matricellular proteins: a sticky affair with cancers. Journal of oncology, 2012, 1-17. , http://hdl.handle.net/10220/17102 , http://dx.doi.org/10.1155/2012/351089
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of oncology
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The multistep process of metastasis is a major hallmark of cancer progression involving the cointeraction and coevolution of the tumor and its microenvironment. In the tumor microenvironment, tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins, which are a family of nonstructural proteins in the extracellular matrix (ECM) that exert regulatory roles via a variety of molecular mechanisms. Matricellular proteins provide signals that support tumorigenic activities characteristic of the metastastic cascade such as epithelial-to-mesenchymal (EMT) transition, angiogenesis, tumor cell motility, proliferation, invasion, evasion from immune surveillance, and survival of anoikis. Herein, we review the current understanding of the following matricellular proteins and highlight their pivotal and multifacted roles in metastatic progression: angiopoietin-like protein 4 (ANGPTL4), CCN family members cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) and CCN6, osteopontin (OPN), secreted protein acidic and rich in cysteine (SPARC), tenascin C (TNC), and thrombospondin-1 and -2 (TSP1, TSP2). Insights into the signaling mechanisms resulting from the interaction of these matricellular proteins and their respective molecular partner(s), as well as their subsequent contribution to tumor metastasis, are discussed. In addition, emerging evidences of their promising potential as therapeutic options and/or targets in the treatment of cancer are also highlighted.

บรรณานุกรม :
Chong, Han Chung , Tan, Chek Kun , Huang, Royston-Luke , Tan, Nguan Soon . (2555). Matricellular proteins : a sticky affair with cancers.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chong, Han Chung , Tan, Chek Kun , Huang, Royston-Luke , Tan, Nguan Soon . 2555. "Matricellular proteins : a sticky affair with cancers".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chong, Han Chung , Tan, Chek Kun , Huang, Royston-Luke , Tan, Nguan Soon . "Matricellular proteins : a sticky affair with cancers."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Chong, Han Chung , Tan, Chek Kun , Huang, Royston-Luke , Tan, Nguan Soon . Matricellular proteins : a sticky affair with cancers. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.