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Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin
นักวิจัย : Setyawati, M. I. , Tay, Chor Yong , Chia, S. L. , Goh, S. L. , Fang, W. , Neo, M. J. , Chong, Han Chung , Tan, S.M. , Loo, Say Chye Joachim , Ng, K. W. , Xie, J. P. , Ong, C. N. , Tan, N. S. , Leong, David Tai Wei
คำค้น : DRNTU::Engineering::Materials::Nanostructured materials.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Setyawati, M., Tay, C. Y., Chia, S., Goh, S., Fang, W., Neo, M., et al. (2013). Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin. Nature communications, 4, 1673-. , 2041-1723 , http://hdl.handle.net/10220/18159 , http://dx.doi.org/10.1038/ncomms2655
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Nature communications
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The use of nanomaterials has raised safety concerns, as their small size facilitates accumulation in and interaction with biological tissues. Here we show that exposure of endothelial cells to TiO2 nanomaterials causes endothelial cell leakiness. This effect is caused by the physical interaction between TiO2 nanomaterials and endothelial cells’ adherens junction protein VE-cadherin. As a result, VE-cadherin is phosphorylated at intracellular residues (Y658 and Y731), and the interaction between VE-cadherin and p120 as well as β-catenin is lost. The resulting signalling cascade promotes actin remodelling, as well as internalization and degradation of VE-cadherin. We show that injections of TiO2 nanomaterials cause leakiness of subcutaneous blood vessels in mice and, in a melanoma-lung metastasis mouse model, increase the number of pulmonary metastases. Our findings uncover a novel non-receptor-mediated mechanism by which nanomaterials trigger intracellular signalling cascades via specific interaction with VE-cadherin, resulting in nanomaterial-induced endothelial cell leakiness.

บรรณานุกรม :
Setyawati, M. I. , Tay, Chor Yong , Chia, S. L. , Goh, S. L. , Fang, W. , Neo, M. J. , Chong, Han Chung , Tan, S.M. , Loo, Say Chye Joachim , Ng, K. W. , Xie, J. P. , Ong, C. N. , Tan, N. S. , Leong, David Tai Wei . (2556). Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Setyawati, M. I. , Tay, Chor Yong , Chia, S. L. , Goh, S. L. , Fang, W. , Neo, M. J. , Chong, Han Chung , Tan, S.M. , Loo, Say Chye Joachim , Ng, K. W. , Xie, J. P. , Ong, C. N. , Tan, N. S. , Leong, David Tai Wei . 2556. "Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Setyawati, M. I. , Tay, Chor Yong , Chia, S. L. , Goh, S. L. , Fang, W. , Neo, M. J. , Chong, Han Chung , Tan, S.M. , Loo, Say Chye Joachim , Ng, K. W. , Xie, J. P. , Ong, C. N. , Tan, N. S. , Leong, David Tai Wei . "Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Setyawati, M. I. , Tay, Chor Yong , Chia, S. L. , Goh, S. L. , Fang, W. , Neo, M. J. , Chong, Han Chung , Tan, S.M. , Loo, Say Chye Joachim , Ng, K. W. , Xie, J. P. , Ong, C. N. , Tan, N. S. , Leong, David Tai Wei . Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.