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Designing drug-loaded multi-layered polymeric microparticles

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Designing drug-loaded multi-layered polymeric microparticles
นักวิจัย : Lee, Wei Li , Widjaja, Effendi , Loo, Say Chye Joachim
คำค้น : DRNTU::Engineering::Materials
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2554
อ้างอิง : Lee, W. L., Widjaja, E., & Loo, S. C. J. (2012). Designing drug-loaded multi-layered polymeric microparticles. Journal of materials science : materials in medicine, 23(1), 81-88. , http://hdl.handle.net/10220/18090 , http://dx.doi.org/10.1007/s10856-011-4508-z
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of materials science : materials in medicine
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

This work reports how novel multi-layered (from double-layered to quadruple-layered) microparticles comprising immiscible polymers can be fabricated through a simple, economical, reliable and versatile one-step solvent evaporation method. These multi-layered microparticles would be excellent candidates to overcome problems inherent in single-layered microparticles for drug delivery. Particle morphologies, layer configurations, and drug distribution were determined by scanning electron microscopy and Raman mapping. Key process parameters achieving the formation of the multi-layered structure were identified. Encapsulation of multiple drugs and layer localization of these drugs within these multi-layered microparticles have also shown to be possible, which were driven by drug-polymer affinity. This one-step fabrication technique can therefore be used for tailoring particle designs, thus facilitating the development of multiparticulate drug delivery devices.

บรรณานุกรม :
Lee, Wei Li , Widjaja, Effendi , Loo, Say Chye Joachim . (2554). Designing drug-loaded multi-layered polymeric microparticles.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Wei Li , Widjaja, Effendi , Loo, Say Chye Joachim . 2554. "Designing drug-loaded multi-layered polymeric microparticles".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Wei Li , Widjaja, Effendi , Loo, Say Chye Joachim . "Designing drug-loaded multi-layered polymeric microparticles."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2554. Print.
Lee, Wei Li , Widjaja, Effendi , Loo, Say Chye Joachim . Designing drug-loaded multi-layered polymeric microparticles. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2554.