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Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity
นักวิจัย : Yang, Xiao , Teoh, Swee-Hin , DasDe, Shamal , Lee, Taeyong
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Yang, X., Teoh, S.-H., DasDe, S., & Lee, T. (2013). Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity. Journal of the mechanical behavior of biomedical materials, 22,51-58. , 1751-6161 , http://hdl.handle.net/10220/18058 , http://dx.doi.org/10.1016/j.jmbbm.2013.03.009
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of the mechanical behavior of biomedical materials
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

In this study, the bone mineral density (BMD), geometry, macroscopic viscoelastic properties and mechanical strength in five different groups of Sprague-Dawley rats (sham operated, ovariectomized with vehicle, parathyroid hormone and/or ibandronate administration) were examined by peripheral quantitative computed tomography (pQCT), dynamic mechanical analysis (DMA) and three-point bending test. At the end of the study, storage modulus (E′), loss tangent (tan δ), ultimate force (Fu) and stiffness (S) had greatly decreased in vehicle-treated ovariectomized group as compared to sham group (p<0.05). The concurrent administration of parathyroid hormone and ibandronate group exhibited the largest cortical area (Ct.Ar) and thickness (Ct.Th), E′, tan δ (0.3 Hz) and subsequently highest Fu as compared to the mono-therapy groups (p<0.05). However, significant changes were not observed in the BMD values of different groups (p>0.05). The relationships between these potential predictors of bone strength (E′, tan δ, BMD and Ct.Ar) and bone mechanical strength parameters (Fu, S and ultimate stress σu) were also examined. Interestingly, during normal daily activity frequency range (0.9–6 Hz), tan δ and Fu were positively correlated. Taken together, these data suggest that DMA can serve as an effective tool to assess bone strength which would be ignored under the normal clinical screenings due to an unchanged BMD. DMA can therefore be used as a better tool to assess the osteoporotic drug efficacy.

บรรณานุกรม :
Yang, Xiao , Teoh, Swee-Hin , DasDe, Shamal , Lee, Taeyong . (2556). Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yang, Xiao , Teoh, Swee-Hin , DasDe, Shamal , Lee, Taeyong . 2556. "Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yang, Xiao , Teoh, Swee-Hin , DasDe, Shamal , Lee, Taeyong . "Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Yang, Xiao , Teoh, Swee-Hin , DasDe, Shamal , Lee, Taeyong . Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.