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Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium
นักวิจัย : Seet, Li-Fong , Tong, Louis , Su, Roseline , Wong, Tina T.
คำค้น : DRNTU::Science::Medicine::Biomedical engineering
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Seet, L.-F., Tong L., Su, R., & Wong T. T. (2012). Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium. Investigative Ophthalmology & Visual Science, 53(2), 587-595. , http://hdl.handle.net/10220/16986 , http://dx.doi.org/10.1167/iovs.11-7941
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Investigative ophtalmology & visual science
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Purpose. To investigate the expression of SPARC and matrix metalloproteinases (MMPs) in normal conjunctiva and pterygium tissues. Methods. This study involved paired control or uninvolved conjunctiva and pterygium tissue from 21 patients. Quantitative real-time PCR was performed to assess SPARC and MMP mRNA expression, whereas Western blot analysis was performed to assess SPARC protein levels in normal conjunctiva and pterygium tissue. Tissue localization of SPARC, extracellular matrix proteins, and MMPs were determined by immunofluorescence analyses. Results. SPARC transcript and protein levels were upregulated in pterygium compared with normal conjunctiva. Immunofluorescence analyses showed localization of SPARC to the epithelial basement membrane and stroma of normal conjunctiva tissue. Increased SPARC in the pterygium stroma colocalized partially with elevated collagen I, fibronectin, α-SMA, and MMP-3. SPARC and MMP-3 also colocalized in the pterygium epithelium. Conclusions. SPARC was upregulated in pterygium and may collaborate with increased MMP-3 in some patients to account for many of the phenotypic properties characteristic of pterygium.

บรรณานุกรม :
Seet, Li-Fong , Tong, Louis , Su, Roseline , Wong, Tina T. . (2555). Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Seet, Li-Fong , Tong, Louis , Su, Roseline , Wong, Tina T. . 2555. "Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Seet, Li-Fong , Tong, Louis , Su, Roseline , Wong, Tina T. . "Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Seet, Li-Fong , Tong, Louis , Su, Roseline , Wong, Tina T. . Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.