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Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-c kinase 1 (RACK1).

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-c kinase 1 (RACK1).
นักวิจัย : Feng, Chen , Li, Yan Feng , Yau, Yin Hoe , Lee, Hui-Shan , Tang, Xiao-Yan , Xue, Zhi-Hong , Zhou, Yi-Chao , Lim, Wei-Min , Cornvik, Tobias Carl , Ruedl, Christiane , Shochat, Susana Geifman , Tan, Suet Mien
คำค้น : DRNTU::Science::Biological sciences.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Feng, C., Li, Y. F., Yau, Y. H., Lee, H. S., Tang, X. Y., Xue, Z. H., et al. (2012). Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-c kinase 1 (RACK1). The journal of biological chemistry, 287(14), 10714-10726. , http://hdl.handle.net/10220/16987 , http://dx.doi.org/10.1074/jbc.M111.299594
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : The journal of biological chemistry
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Integrins are heterodimeric type I membrane cell adhesion molecules that are involved in many biological processes. Integrins are bidirectional signal transducers because their cytoplasmic tails are docking sites for cytoskeletal and signaling molecules. Kindlins are cytoplasmic molecules that mediate inside-out signaling and activation of the integrins. The three kindlin paralogs in humans are kindlin-1, -2, and -3. Each of these contains a 4.1-ezrin-radixin-moesin (FERM) domain and a pleckstrin homology domain. Kindlin-3 is expressed in platelets, hematopoietic cells, and endothelial cells. Here we show that kindlin-3 is involved in integrin αLβ2 outside-in signaling. It also promotes micro-clustering of integrin αLβ2. We provide evidence that kindlin-3 interacts with the receptor for activated-C kinase 1 (RACK1), a scaffold protein that folds into a seven-blade propeller. This interaction involves the pleckstrin homology domain of kindlin-3 and blades 5–7 of RACK1. Using the SKW3 human T lymphoma cells, we show that integrin αLβ2 engagement by its ligand ICAM-1 promotes the association of kindlin-3 with RACK1. We also show that kindlin-3 co-localizes with RACK1 in polarized SKW3 cells and human T lymphoblasts. Our findings suggest that kindlin-3 plays an important role in integrin αLβ2 outside-in signaling.

บรรณานุกรม :
Feng, Chen , Li, Yan Feng , Yau, Yin Hoe , Lee, Hui-Shan , Tang, Xiao-Yan , Xue, Zhi-Hong , Zhou, Yi-Chao , Lim, Wei-Min , Cornvik, Tobias Carl , Ruedl, Christiane , Shochat, Susana Geifman , Tan, Suet Mien . (2555). Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-c kinase 1 (RACK1)..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Feng, Chen , Li, Yan Feng , Yau, Yin Hoe , Lee, Hui-Shan , Tang, Xiao-Yan , Xue, Zhi-Hong , Zhou, Yi-Chao , Lim, Wei-Min , Cornvik, Tobias Carl , Ruedl, Christiane , Shochat, Susana Geifman , Tan, Suet Mien . 2555. "Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-c kinase 1 (RACK1).".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Feng, Chen , Li, Yan Feng , Yau, Yin Hoe , Lee, Hui-Shan , Tang, Xiao-Yan , Xue, Zhi-Hong , Zhou, Yi-Chao , Lim, Wei-Min , Cornvik, Tobias Carl , Ruedl, Christiane , Shochat, Susana Geifman , Tan, Suet Mien . "Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-c kinase 1 (RACK1).."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Feng, Chen , Li, Yan Feng , Yau, Yin Hoe , Lee, Hui-Shan , Tang, Xiao-Yan , Xue, Zhi-Hong , Zhou, Yi-Chao , Lim, Wei-Min , Cornvik, Tobias Carl , Ruedl, Christiane , Shochat, Susana Geifman , Tan, Suet Mien . Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-c kinase 1 (RACK1).. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.