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Inhibition of HBV-induced angiogenesis by ibuprofen : role of HBx

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Inhibition of HBV-induced angiogenesis by ibuprofen : role of HBx
นักวิจัย : Zhang, Jianhua , Chen, William Wei Ning
คำค้น : DRNTU::Science::Medicine
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Zhang, J., & Chen, W. N. W. (2012). Inhibition of HBV-induced angiogenesis by ibuprofen : role of HBx. Interventional medicine and applied science, 4(1), 21-31. , http://hdl.handle.net/10220/17190 , http://dx.doi.org/10.1556/IMAS.4.2012.1.5
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Interventional medicine and applied science
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Chronic hepatitis B virus (HBV) carriers may develop hepatocellular carcinoma (HCC) by a wide range of mechanisms including angiogenesis. We show that HBV replication induces the expression of angiogenic proteins interleukin 6 (IL6) and cyclooxygenase-2 (Cox2). Interestingly, ibuprofen (a Cox2 inhibitor) is found to attenuate the levels of IL6 and Cox 2 which are induced by HBV replication.The mechanism of attenuation of angiogenic proteins by ibuprofen was further investigated. Our results show that HBx is involved in the increase of the expression of Cox2 through the NFκB pathway. However, the expression of Cox2 is decreased when the HBx-expressing cells are incubated with ibuprofen. The contrasting effect of HBx on Cox2 is found to be determined by differential dimer formation among the members of the NFκB family of proteins, including NFκB, RelA, and C-rel. Specifically, HBx alone results in dimer formation between NFκB and RelA, while the combined presence of HBx and ibuprofen leads to the formation of NFκB and C-rel. Additional information on the interaction network involving HBx, ibuprofen, and NFκB pathways is revealed by two-dimensional liquid chromatography-tandem mass spectrometry proteomics analysis. Taken together, our findings provide new insights on the angiogenesis induced by HBV replication.

บรรณานุกรม :
Zhang, Jianhua , Chen, William Wei Ning . (2555). Inhibition of HBV-induced angiogenesis by ibuprofen : role of HBx.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhang, Jianhua , Chen, William Wei Ning . 2555. "Inhibition of HBV-induced angiogenesis by ibuprofen : role of HBx".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhang, Jianhua , Chen, William Wei Ning . "Inhibition of HBV-induced angiogenesis by ibuprofen : role of HBx."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Zhang, Jianhua , Chen, William Wei Ning . Inhibition of HBV-induced angiogenesis by ibuprofen : role of HBx. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.