ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Dry powder inhaler formulation of lipid–polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Dry powder inhaler formulation of lipid–polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles
นักวิจัย : Yang, Yue , Cheow, Wean Sin , Hadinoto, Kunn
คำค้น : DRNTU::Engineering::Chemical engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Yang, Y., Cheow, W. S., & Hadinoto, K. (2012). Dry powder inhaler formulation of lipid–polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles. International journal of pharmaceutics, 434(1-2), 49-58. , 0378-5173 , http://hdl.handle.net/10220/16847 , http://dx.doi.org/10.1016/j.ijpharm.2012.05.036
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : International journal of pharmaceutics
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Lipid–polymer hybrid nanoparticles have emerged as promising nanoscale carriers of therapeutics as they combine the attractive characteristics of liposomes and polymers. Herein we develop dry powder inhaler (DPI) formulation of hybrid nanoparticles composed of poly(lactic-co-glycolic acid) and soybean lecithin as the polymer and lipid constituents, respectively. The hybrid nanoparticles are transformed into inhalable microscale nanocomposite structures by a novel technique based on electrostatically-driven adsorption of nanoparticles onto polysaccharide carrier particles, which eliminates the drawbacks of conventional techniques based on controlled drying (e.g. nanoparticle-specific formulation, low yield). First, we engineer polysaccharide carrier particles made up of chitosan cross-linked with tripolyphosphate and dextran sulphate to exhibit the desired aerosolization characteristics and physical robustness. Second, we investigate the effects of nanoparticle to carrier mass ratio and salt inclusion on the adsorption efficiency, in terms of the nanoparticle loading and yield, from which the optimal formulation is determined. Desorption of the nanoparticles from the carrier particles in phosphate buffer saline is also examined. Lastly, we characterize aerosolization efficiency of the nanocomposite product in vitro, where the emitted dose and respirable fraction are found to be comparable to the values of conventional DPI formulations.

บรรณานุกรม :
Yang, Yue , Cheow, Wean Sin , Hadinoto, Kunn . (2555). Dry powder inhaler formulation of lipid–polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yang, Yue , Cheow, Wean Sin , Hadinoto, Kunn . 2555. "Dry powder inhaler formulation of lipid–polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yang, Yue , Cheow, Wean Sin , Hadinoto, Kunn . "Dry powder inhaler formulation of lipid–polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Yang, Yue , Cheow, Wean Sin , Hadinoto, Kunn . Dry powder inhaler formulation of lipid–polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.