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A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation
นักวิจัย : Feng, Chao , Zhou, Liying , Yu, Ting , Xu, Gang , Tian, Hong-Lei , Xu, Jin-Jie , Xu, Hong-Xi , Luo, Kathy Qian
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2554
อ้างอิง : Feng, C., Zhou, L.-Y., Yu, T., Xu, G., Tian, H.-L., Xu, J.-J., Xu, H.-X., & Luo, K. Q. (2012). A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation. International Journal of Cancer, 131(6), 1445-1454. , 0020-7136 , http://hdl.handle.net/10220/16943 , http://dx.doi.org/10.1002/ijc.27365
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : International journal of cancer
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Oblongifolin C (OC) was identified as a potent apoptosis inducer from an herbal plant, Garcinia yunnanensis, during our previous bioassay-guided drug screening. In this study, we investigated the signaling pathways through which OC activated apoptosis in HeLa cells. We also compared the IC50 values of OC with that of etoposide, paclitaxel and vinblastine in multiple cancer cell lines including HER2 and P-glycoprotein overexpressing cells. In addition, the in vivo antitumor effect of OC was studied in nude mice model. Our results showed that OC induced a caspase-dependent apoptosis by triggering a series of events in HeLa cells including Bax translocation, cytochrome c release, caspase-3 activation, chromosome fragmentation followed by caspase-8 activation, Bid cleavage and eventually cell death. Addition of a pan-caspase inhibitor or overexpression of an anti-apoptotic protein, Bcl-xL, prevented OC-induced cell death. Moreover, OC exhibited a wide anticancer spectrum in multiple cancer cell lines with comparable IC50 values, regardless of the expression levels of HER2 and P-glycoprotein. In contrast, the IC50 values of three clinical anticancer drugs, etoposide, paclitaxel and vinblastine were significantly elevated in HER2 and/or P-glycoprotein overexpressing cells. Furthermore, OC showed a similar antitumor effect but lower general toxicity than etoposide against xenografted human tumors in nude mice model. All these data suggested that OC is a promising apoptosis inducer with the potential to be developed into a clinical anticancer drug.

บรรณานุกรม :
Feng, Chao , Zhou, Liying , Yu, Ting , Xu, Gang , Tian, Hong-Lei , Xu, Jin-Jie , Xu, Hong-Xi , Luo, Kathy Qian . (2554). A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Feng, Chao , Zhou, Liying , Yu, Ting , Xu, Gang , Tian, Hong-Lei , Xu, Jin-Jie , Xu, Hong-Xi , Luo, Kathy Qian . 2554. "A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Feng, Chao , Zhou, Liying , Yu, Ting , Xu, Gang , Tian, Hong-Lei , Xu, Jin-Jie , Xu, Hong-Xi , Luo, Kathy Qian . "A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2554. Print.
Feng, Chao , Zhou, Liying , Yu, Ting , Xu, Gang , Tian, Hong-Lei , Xu, Jin-Jie , Xu, Hong-Xi , Luo, Kathy Qian . A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2554.