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A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation
นักวิจัย : Yu, Ting , Chua, Chee Kai , Tay, Chor Yong , Wen, Feng , Yu, Haiyang , Chan, Jerry Kok Yen , Chong, Mark Seow Khoon , Leong, David Tai Wei , Tan, Lay Poh
คำค้น : DRNTU::Engineering::Chemical engineering::Biochemical engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Yu, T., Chua, C. K., Tay, C. Y., Wen, F., Yu, H., Chan, J. K. Y., et al. (2013). A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation. Macromolecular bioscience, 13(6), 799-807. , 1616-5187 , http://hdl.handle.net/10220/16726 , http://dx.doi.org/10.1002/mabi.201200481
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Macromolecular bioscience
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Human mesenchymal stem cells (MSCs) derived from various origins show varied differentiation capability. Recent work shows that cell shape manipulation via micropatterning can modulate the differentiation of bone-marrow-derived MSCs. Herein, the effect of micropatterning on the myogenesis of MSCs isolated from three different sources (bone marrow, fetal tissue, and adipose) is reported. All the well-aligned cells, regardless of source, predominantly commit to myogenic lineage, as shown by the significant upregulation of myogenic gene markers and positive myosin heavy chain staining. It is demonstrated that our novel micropattern can be used as a generic platform for inducing myogenesis of MSCs from different sources and may also have the potential to be extended to induce other lineage commitment.

บรรณานุกรม :
Yu, Ting , Chua, Chee Kai , Tay, Chor Yong , Wen, Feng , Yu, Haiyang , Chan, Jerry Kok Yen , Chong, Mark Seow Khoon , Leong, David Tai Wei , Tan, Lay Poh . (2556). A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yu, Ting , Chua, Chee Kai , Tay, Chor Yong , Wen, Feng , Yu, Haiyang , Chan, Jerry Kok Yen , Chong, Mark Seow Khoon , Leong, David Tai Wei , Tan, Lay Poh . 2556. "A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yu, Ting , Chua, Chee Kai , Tay, Chor Yong , Wen, Feng , Yu, Haiyang , Chan, Jerry Kok Yen , Chong, Mark Seow Khoon , Leong, David Tai Wei , Tan, Lay Poh . "A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Yu, Ting , Chua, Chee Kai , Tay, Chor Yong , Wen, Feng , Yu, Haiyang , Chan, Jerry Kok Yen , Chong, Mark Seow Khoon , Leong, David Tai Wei , Tan, Lay Poh . A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.