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A facile synthesis of strong near infrared fluorescent layered double hydroxide nanovehicles with an anticancer drug for tumor optical imaging and therapy

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : A facile synthesis of strong near infrared fluorescent layered double hydroxide nanovehicles with an anticancer drug for tumor optical imaging and therapy
นักวิจัย : Chen, Chunping , Yee, Lee Kim , Gong, Hua , Zhang, Yong , Xu, Rong
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Chen, C., Yee, L. K., Gong, H., Zhang, Y.,& Xu, R. (2013). A facile synthesis of strong near infrared fluorescent layered double hydroxide nanovehicles with an anticancer drug for tumor optical imaging and therapy. Nanoscale, 5(10), 4314-4320. , http://hdl.handle.net/10220/16655 , http://dx.doi.org/10.1039/c3nr00781b
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Nanoscale
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

In this work, a new multifunctional nanovehicle for tumor optical imaging and therapy was developed using Y2O3:Er3+,Yb3+ nanoparticles as near infrared fluorescent nanophosphors, and MgAl-layered double hydroxide (LDH) nanosheets as anticancer drug nanovehicles. Monodispersed Y2O3:Er3+,Yb3+ nanophosphors were readily synthesized by the urea assisted homogenous precipitation method. Hierarchically structured LDH nanosheets intercalated with an anticancer drug, fluorouracil (5FU), were deposited on the surface of Y2O3:Er3+,Yb3+@SiO2 by a simple precipitation method followed by hydrothermal treatment. The resultant Y2O3:Er3+,Yb3+@SiO2@LDH-5FU nanovehicles exhibit strong red upconversion fluorescence under the excitation of a 980 nm laser, which allows tracking of the nanovehicles after localization in cancer cells. A better anticancer efficiency was obtained over the nanovehicles than the free drug which can be attributed to their positively charged surfaces for favorable interaction with the negatively charged cell membranes. The multifunctional nanovehicles designed in this work are expected to be promising material candidates for simultaneous tumor optical imaging and therapy.

บรรณานุกรม :
Chen, Chunping , Yee, Lee Kim , Gong, Hua , Zhang, Yong , Xu, Rong . (2556). A facile synthesis of strong near infrared fluorescent layered double hydroxide nanovehicles with an anticancer drug for tumor optical imaging and therapy.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chen, Chunping , Yee, Lee Kim , Gong, Hua , Zhang, Yong , Xu, Rong . 2556. "A facile synthesis of strong near infrared fluorescent layered double hydroxide nanovehicles with an anticancer drug for tumor optical imaging and therapy".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chen, Chunping , Yee, Lee Kim , Gong, Hua , Zhang, Yong , Xu, Rong . "A facile synthesis of strong near infrared fluorescent layered double hydroxide nanovehicles with an anticancer drug for tumor optical imaging and therapy."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Chen, Chunping , Yee, Lee Kim , Gong, Hua , Zhang, Yong , Xu, Rong . A facile synthesis of strong near infrared fluorescent layered double hydroxide nanovehicles with an anticancer drug for tumor optical imaging and therapy. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.