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FUSE : a system for data-driven multi-level functional summarization of protein interaction networks

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : FUSE : a system for data-driven multi-level functional summarization of protein interaction networks
นักวิจัย : Seah, Boon-Siew , Bhowmick, Sourav S. , Dewey Jr., C. Forbes , Yu, Hanry
คำค้น : DRNTU::Engineering::Computer science and engineering::Computing methodologies::Simulation and modeling.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Seah, B.-S., Bhowmick, S. S., Dewey, C. F., & Yu, H. (2012). FUSE : a system for data-driven multi-level functional summarization of protein interaction networks. Proceedings of the 2nd ACM SIGHIT International Health Informatics Symposium, pp847-850. , http://hdl.handle.net/10220/16669 , http://dx.doi.org/10.1145/2110363.2110470
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Despite recent progress in high-throughput experimental studies, systems level visualization and analysis of large protein interaction networks (PPI) remains a challenging task, given its scale and high-dimensionality. Specifically, techniques that automatically abstract and summarize PPIs at multiple resolutions to provide high level views of its functional landscape are still lacking. In this demonstration, we present a novel data-driven and generic system called FUSE (Functional Summary Generator) that generates functional maps of a PPI at different levels of organization, from broad process-process level interactions to in-depth complex-complex level interactions. By simultaneously evaluating interaction and annotation data, FUSE abstracts higher-order interaction maps by reducing the details of the underlying PPI to form a functional summary graph of interconnected functional clusters. We demonstrate various innovative features of FUSE which aid users to visualize these summaries in a user-friendly manner and navigate through complex PPIs.

บรรณานุกรม :
Seah, Boon-Siew , Bhowmick, Sourav S. , Dewey Jr., C. Forbes , Yu, Hanry . (2555). FUSE : a system for data-driven multi-level functional summarization of protein interaction networks.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Seah, Boon-Siew , Bhowmick, Sourav S. , Dewey Jr., C. Forbes , Yu, Hanry . 2555. "FUSE : a system for data-driven multi-level functional summarization of protein interaction networks".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Seah, Boon-Siew , Bhowmick, Sourav S. , Dewey Jr., C. Forbes , Yu, Hanry . "FUSE : a system for data-driven multi-level functional summarization of protein interaction networks."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Seah, Boon-Siew , Bhowmick, Sourav S. , Dewey Jr., C. Forbes , Yu, Hanry . FUSE : a system for data-driven multi-level functional summarization of protein interaction networks. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.