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Control of adipogenesis by the autocrine interplays between angiotensin 1–7/mas receptor and angiotensin II/AT1 receptor signaling pathways

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Control of adipogenesis by the autocrine interplays between angiotensin 1–7/mas receptor and angiotensin II/AT1 receptor signaling pathways
นักวิจัย : Than, Aung , Leow, Melvin Khee-Shing , Chen, Peng
คำค้น : DRNTU::Science::Biological sciences::Biochemistry
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Than, A., Leow, M. K. S., & Chen, P. (2013). Control of Adipogenesis by the Autocrine Interplays between Angiotensin 1–7/Mas Receptor and Angiotensin II/AT1 Receptor Signaling Pathways. The Journal of Biological Chemistry, 288(24), 15520-15531. , 1083-351X , http://hdl.handle.net/10220/16679 , http://dx.doi.org/10.1074/jbc.M113.459792
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of biological chemistry
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Angiotensin II (AngII), a peptide hormone released by adipocytes, can be catabolized by adipose angiotensin-converting enzyme 2 (ACE2) to form Ang(1-7). Co-expression of AngII receptors (AT1 and AT2) and Ang(1-7) receptors (Mas) in adipocytes implies the autocrine regulation of the local angiotensin system upon adipocyte functions, through yet unknown interactive mechanisms. In the present study, we reveal the adipogenic effects of Ang(1-7) through activation of Mas receptor and its subtle interplays with the antiadipogenic AngII-AT1 signaling pathways. Specifically, in human and 3T3-L1 preadipocytes, Ang(1-7)-Mas signaling promotes adipogenesis via activation of PI3K/Akt and inhibition of MAPK kinase/ERK pathways, and Ang(1-7)-Mas antagonizes the antiadipogenic effect of AngII-AT1 by inhibiting the AngII-AT1-triggered MAPK kinase/ERK pathway. The autocrine regulation of the AngII/AT1-ACE2-Ang(1-7)/Mas axis upon adipogenesis has also been revealed. This study suggests the importance of the local regulation of the delicately balanced angiotensin system upon adipogenesis and its potential as a novel therapeutic target for obesity and related metabolic disorders.

บรรณานุกรม :
Than, Aung , Leow, Melvin Khee-Shing , Chen, Peng . (2556). Control of adipogenesis by the autocrine interplays between angiotensin 1–7/mas receptor and angiotensin II/AT1 receptor signaling pathways.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Than, Aung , Leow, Melvin Khee-Shing , Chen, Peng . 2556. "Control of adipogenesis by the autocrine interplays between angiotensin 1–7/mas receptor and angiotensin II/AT1 receptor signaling pathways".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Than, Aung , Leow, Melvin Khee-Shing , Chen, Peng . "Control of adipogenesis by the autocrine interplays between angiotensin 1–7/mas receptor and angiotensin II/AT1 receptor signaling pathways."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Than, Aung , Leow, Melvin Khee-Shing , Chen, Peng . Control of adipogenesis by the autocrine interplays between angiotensin 1–7/mas receptor and angiotensin II/AT1 receptor signaling pathways. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.