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Cenderitide-eluting film for potential cardiac patch applications.

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Cenderitide-eluting film for potential cardiac patch applications.
นักวิจัย : Ng, Xu Wen. , Huang, Yingying. , Chen, Horng H. , Burnett Jr, John C. , Boey, Freddy Yin Chiang , Venkatraman, Subbu S.
คำค้น : DRNTU::Engineering::Materials.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Ng, X. W., Huang, Y., Chen, H. H., Burnett Jr, J. C., Boey, F. Y. C.,& Venkatraman, S. S. (2013). Cenderitide-eluting film for potential cardiac patch applications. PLoS ONE, 8(7), e68346. , 1932-6203 , http://hdl.handle.net/10220/16525 , http://dx.doi.org/10.1371/journal.pone.0068346
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : PLoS ONE
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Cenderitide, also known as CD-NP, is a designer peptide developed by combining native mammalian c-type natriuretic peptide (CNP) and the C-terminus isolated from the dendroapis natriuretic peptide (DNP) of the venom from the green mamba. In early studies, intravenous and subcutaneous infusion of cenderitide was reported to reduce left ventricular (LV) mass and ameliorate cardiac remodelling. In this work, biodegradable polymeric films encapsulating CD-NP were developed and were investigated for their in vitro release and degradation characteristics. Subsequently, the bioactivity of released peptide and its effects on human cardiac fibroblast (HCF) were explored. We achieved sustained release from three films with low, intermediate and high release profiles for 30 days. Moreover, the bioactivity of released peptide was verified from the elevated production of cyclic guanosine monophospate (cGMP). The CD-NP released from films was able to inhibit the proliferation of hypertrophic HCF as well as suppress DNA synthesis in HCF. Furthermore, the sustained delivery from films showed comparable or superior suppressive actions on hypertrophic HCF compared to daily infusion of CD-NP. The results suggest that these films could be used to inhibit fibrosis and reduce cardiac remodelling via local delivery as cardiac patches.

บรรณานุกรม :
Ng, Xu Wen. , Huang, Yingying. , Chen, Horng H. , Burnett Jr, John C. , Boey, Freddy Yin Chiang , Venkatraman, Subbu S. . (2556). Cenderitide-eluting film for potential cardiac patch applications..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ng, Xu Wen. , Huang, Yingying. , Chen, Horng H. , Burnett Jr, John C. , Boey, Freddy Yin Chiang , Venkatraman, Subbu S. . 2556. "Cenderitide-eluting film for potential cardiac patch applications.".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ng, Xu Wen. , Huang, Yingying. , Chen, Horng H. , Burnett Jr, John C. , Boey, Freddy Yin Chiang , Venkatraman, Subbu S. . "Cenderitide-eluting film for potential cardiac patch applications.."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Ng, Xu Wen. , Huang, Yingying. , Chen, Horng H. , Burnett Jr, John C. , Boey, Freddy Yin Chiang , Venkatraman, Subbu S. . Cenderitide-eluting film for potential cardiac patch applications.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.