ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria
นักวิจัย : Ch'ng, Jun-Hong , Mok, Sachel , Bozdech, Zbynek , Lear, Martin James , Boudhar, Aicha , Russell, Bruce , Nosten, Francois , Tan, Kevin Shyong-Wei
คำค้น : DRNTU::Science::Biological sciences::Biochemistry
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Ch'ng, J.-H., Mok, S., Bozdech, Z., Lear, M. J., Boudhar, A., Russell, B., Nosten, F., & Tan, K. S.-W. (2013). A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. Scientific reports, 3: 1734. , 2045-2322 , http://hdl.handle.net/10220/16522 , http://dx.doi.org/10.1038/srep01734
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Scientific reports
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Due to the widespread prevalence of resistant parasites, chloroquine (CQ) was removed from front-line antimalarial chemotherapy in the 1990s despite its initial promise of disease eradication. Since then, resistance-conferring mutations have been identified in transporters such as the PfCRT, that allow for the efflux of CQ from its primary site of action, the parasite digestive vacuole. Chemosensitizing/ chemoreversing compounds interfere with the function of these transporters thereby sensitizing parasites to CQ once again. However, compounds identified thus far have disappointing in vivo efficacy and screening for alternative candidates is required to revive this strategy. In this study, we propose a simple and direct means to rapidly screen for such compounds using a fluorescent-tagged CQ molecule. When this screen was applied to a small library, seven novel chemosensitizers (octoclothepin, methiothepin, metergoline, loperamide, chlorprothixene, L-703,606 and mibefradil) were quickly elucidated, including two which showed greater potency than the classical chemosensitizers verapamil and desipramine.

บรรณานุกรม :
Ch'ng, Jun-Hong , Mok, Sachel , Bozdech, Zbynek , Lear, Martin James , Boudhar, Aicha , Russell, Bruce , Nosten, Francois , Tan, Kevin Shyong-Wei . (2556). A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ch'ng, Jun-Hong , Mok, Sachel , Bozdech, Zbynek , Lear, Martin James , Boudhar, Aicha , Russell, Bruce , Nosten, Francois , Tan, Kevin Shyong-Wei . 2556. "A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ch'ng, Jun-Hong , Mok, Sachel , Bozdech, Zbynek , Lear, Martin James , Boudhar, Aicha , Russell, Bruce , Nosten, Francois , Tan, Kevin Shyong-Wei . "A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Ch'ng, Jun-Hong , Mok, Sachel , Bozdech, Zbynek , Lear, Martin James , Boudhar, Aicha , Russell, Bruce , Nosten, Francois , Tan, Kevin Shyong-Wei . A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.