ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs
นักวิจัย : Panda, Parthasarathi , Appalashetti, Manjuvani , Natarajan, Meenubharathi , Mary, Chan-Park , Venkatraman, Subbu S. , Judeh, Zaher M. A.
คำค้น : DRNTU::Engineering::Chemical engineering. , DRNTU::Engineering::Materials.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Panda, P., Appalashetti, M., Natarajan, M., Mary, C. P., Venkatraman, S. S., & Judeh, Z. M. A. (2012). Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs. European journal of medicinal chemistry, 58, 418-430. , http://hdl.handle.net/10220/13751 , http://dx.doi.org/10.1016/j.ejmech.2012.10.034
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : European journal of medicinal chemistry
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The first total synthesis of natural phenylpropanoid sucrose esters (PSEs) helonioside A 1, 3′,4′,6′-tri-O-feruloylsucrose 2 and lapathoside C 3 along with 17 unnatural PSE analogs has been successfully accomplished in a short and simple synthetic route. A selected set of 17 synthesized PSEs were evaluated for the antiproliferative activity against human cervical epithelioid carcinoma (HeLa) cell lines using MTS assay method. Eleven (11) compounds showed significant antiproliferative activity with their IC50values ranging from 0.16 to 6.01 μM. The structure–activity-relationship studies revealed that the antiproliferative activity is influenced by the lipophilicity and number of feruloyl substituents on these compounds. The preliminary screening indicated that these compounds are potentially very valuable source for new lead chemotherapeutics.

บรรณานุกรม :
Panda, Parthasarathi , Appalashetti, Manjuvani , Natarajan, Meenubharathi , Mary, Chan-Park , Venkatraman, Subbu S. , Judeh, Zaher M. A. . (2555). Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Panda, Parthasarathi , Appalashetti, Manjuvani , Natarajan, Meenubharathi , Mary, Chan-Park , Venkatraman, Subbu S. , Judeh, Zaher M. A. . 2555. "Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Panda, Parthasarathi , Appalashetti, Manjuvani , Natarajan, Meenubharathi , Mary, Chan-Park , Venkatraman, Subbu S. , Judeh, Zaher M. A. . "Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Panda, Parthasarathi , Appalashetti, Manjuvani , Natarajan, Meenubharathi , Mary, Chan-Park , Venkatraman, Subbu S. , Judeh, Zaher M. A. . Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.