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The mechanism of antiparallel β-sheet formation based on conditioned self-avoiding walk

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : The mechanism of antiparallel β-sheet formation based on conditioned self-avoiding walk
นักวิจัย : Goh, Boon Chong , Leong, Hon Wai , Qu, Xiaohui , Chew, Lock Yue
คำค้น : DRNTU::Science
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Goh, B. C., Leong, H. W., Qu, X., & Chew, L. Y. (2012). The mechanism of antiparallel β-sheet formation based on conditioned self-avoiding walk. The European physical journal E, 35(4). , http://hdl.handle.net/10220/16223 , http://dx.doi.org/10.1140/epje/i2012-12027-8
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : The European physical journal E
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

By introducing an additional hydrogen bond to hydrogen bond interaction in the force field of the CSAW (Conditioned Self-Avoiding Walk) model, we investigate into the mechanism of antiparallel β-sheet formation based on the folding of a short polyalanine in gas phase. Through our numerical simulation, we detect the possible presence of a transient helix during β-sheet formation, whose presence is shown to have slowed the formation of β-sheets by an order of magnitude. While we observe the mechanisms of nucleation, zipping and induction that drives the formation of a β-sheet, we uncover a new mechanism that involves transient β-turns and short β-sheets during the formation of long β-sheets. Our results have enabled us to provide an overview on the mechanisms of β-sheet formation via two main folding pathways: slow folding through the intermediate state of transient helix, and fast folding from the nucleation of β-turn.

บรรณานุกรม :
Goh, Boon Chong , Leong, Hon Wai , Qu, Xiaohui , Chew, Lock Yue . (2555). The mechanism of antiparallel β-sheet formation based on conditioned self-avoiding walk.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Goh, Boon Chong , Leong, Hon Wai , Qu, Xiaohui , Chew, Lock Yue . 2555. "The mechanism of antiparallel β-sheet formation based on conditioned self-avoiding walk".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Goh, Boon Chong , Leong, Hon Wai , Qu, Xiaohui , Chew, Lock Yue . "The mechanism of antiparallel β-sheet formation based on conditioned self-avoiding walk."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Goh, Boon Chong , Leong, Hon Wai , Qu, Xiaohui , Chew, Lock Yue . The mechanism of antiparallel β-sheet formation based on conditioned self-avoiding walk. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.