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New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics
นักวิจัย : Manavalan, Arulmani , Feng, Lin , Sze, Siu Kwan , Hu, Jiang-Miao , Heese, Klaus
คำค้น : DRNTU::Science::Biological sciences
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Manavalan, A., Feng, L., Sze, S. K., Hu, J., & Heese, K. (2012). New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics. Journal of proteomics, 75(8), 2468–2479. , http://hdl.handle.net/10220/13675 , http://dx.doi.org/10.1016/j.jprot.2012.02.029
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of proteomics
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Gastrodia elata (tianma) is a traditional Chinese herbal medicine (TCM) often used for the treatment of cerebrovascular diseases. In this study, we investigated the effects of tianma on the brain protein metabolism by quantitative proteomics to gain evidence for a direct relationship between tianma treatment and brain functions. One-year-old rats were treated with tianma (~ 2.5 g/kg/day) for 3 months and the brain tissue proteome was analyzed by using the iTRAQ (isobaric tag for relative and absolute quantification) technology. According to our results, the long-term treatment with tianma could modulate the brain protein metabolism at the proteome level by down-regulating the expressions of various proteins, such as Gnao1 and Dctn2, which are related to neuronal growth cone control and synaptic activities. In addition, tianma treatment also induced the up-regulation of molecular chaperons and proteins related to the misfolded protein response, like Anxa5, and also other proteins involved in Huntington's disease (HD) (e.g. Pacsin1 and Arf3). Concluding, tianma could eventually contribute to activities related to synaptic plasticity and neuro-restorative processes and thus might be a novel candidate agent for the treatment of neurodegenerative diseases by regulating the brain proteome.

บรรณานุกรม :
Manavalan, Arulmani , Feng, Lin , Sze, Siu Kwan , Hu, Jiang-Miao , Heese, Klaus . (2555). New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Manavalan, Arulmani , Feng, Lin , Sze, Siu Kwan , Hu, Jiang-Miao , Heese, Klaus . 2555. "New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Manavalan, Arulmani , Feng, Lin , Sze, Siu Kwan , Hu, Jiang-Miao , Heese, Klaus . "New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Manavalan, Arulmani , Feng, Lin , Sze, Siu Kwan , Hu, Jiang-Miao , Heese, Klaus . New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.