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Mitosis-targeted anti-cancer therapies : where they stand.

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Mitosis-targeted anti-cancer therapies : where they stand.
นักวิจัย : Chan, K.-S. , Koh, Cheng Gee. , Li, H.-Y.
คำค้น : DRNTU::Science::Biological sciences.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Chan, K. S., Koh, C. G., & Li, H. Y. (2012). Mitosis-targeted anti-cancer therapies: where they stand. Cell death and disease, 3(10). , 2041-4889 , http://hdl.handle.net/10220/12878 , http://dx.doi.org/10.1038/cddis.2012.148
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Cell death and disease
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The strategy of clinically targeting cancerous cells at their most vulnerable state during mitosis has instigated numerous studies into the mitotic cell death (MCD) pathway. As the hallmark of cancer revolves around cell-cycle deregulation, it is not surprising that antimitotic therapies are effective against the abnormal proliferation of transformed cells. Moreover, these antimitotic drugs are also highly selective and sensitive. Despite the robust rate of discovery and the development of mitosis-selective inhibitors, the unpredictable complexities of the human body’s response to these drugs still herald the biggest challenge towards clinical success. Undoubtedly, the need to bridge the gap between promising preclinical trials and effective translational bedside treatment prompts further investigations towards mapping out the mechanistic pathways of MCD, understanding how these drugs work as medicine in the body and more comprehensive target validations. In this review, current antimitotic agents are summarized with particular emphasis on the evaluation of their clinical efficacy as well as their limitations. In addition, we discuss the basis behind the lack of activity of these inhibitors in human trials and the potential and future directions of mitotic anticancer strategies.

บรรณานุกรม :
Chan, K.-S. , Koh, Cheng Gee. , Li, H.-Y. . (2555). Mitosis-targeted anti-cancer therapies : where they stand..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chan, K.-S. , Koh, Cheng Gee. , Li, H.-Y. . 2555. "Mitosis-targeted anti-cancer therapies : where they stand.".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chan, K.-S. , Koh, Cheng Gee. , Li, H.-Y. . "Mitosis-targeted anti-cancer therapies : where they stand.."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Chan, K.-S. , Koh, Cheng Gee. , Li, H.-Y. . Mitosis-targeted anti-cancer therapies : where they stand.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.