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Molecular dynamics unlocks atomic level self-assembly of the exopolysaccharide matrix of water-treatment granular biofilms

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Molecular dynamics unlocks atomic level self-assembly of the exopolysaccharide matrix of water-treatment granular biofilms
นักวิจัย : Seviour, Thomas , Malde, Alpeshkumar K. , Kjelleberg, Staffan , Yuan, Zhiguo , Mark, Alan E.
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Seviour, T., Malde, A. K., Kjelleberg, S., Yuan, Z.,& Mark, A. E. (2012). Molecular Dynamics Unlocks Atomic Level Self-Assembly of the Exopolysaccharide Matrix of Water-Treatment Granular Biofilms. Biomacromolecules, 13(6), 1965-1972. , http://hdl.handle.net/10220/12866 , http://dx.doi.org/10.1021/bm3005808
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Biomacromolecules
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Biofilm formation, in which bacteria are embedded within an extracellular matrix, is the default form of microbial life in most natural and engineered habitats. In this work, atomistic molecular dynamics simulations were employed to examine the self-assembly of the polysaccharide Granulan to provide insight into the molecular interactions that lead to biofilm formation. Granulan is a major gel forming matrix component of granular microbial biofilms found in used-water treatment systems. Molecular dynamics simulations showed that Granulan forms an antiparallel double helix stabilized by complementary hydrogen bonds between the β-glucosamine of one strand and the N-acetyl-β-galactosamine–2-acetoamido-2-deoxy-α-galactopyranuronic pair of the other in both the presence and absence of Ca2+. It is shown that Ca2+ binds primarily to the carboxyl group of the terminal hexuronic acid of the sugar branch and that interactions between branches mediated by Ca2+ suggest a possible mechanism for strengthening gels by facilitating interhelical bridging.

บรรณานุกรม :
Seviour, Thomas , Malde, Alpeshkumar K. , Kjelleberg, Staffan , Yuan, Zhiguo , Mark, Alan E. . (2555). Molecular dynamics unlocks atomic level self-assembly of the exopolysaccharide matrix of water-treatment granular biofilms.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Seviour, Thomas , Malde, Alpeshkumar K. , Kjelleberg, Staffan , Yuan, Zhiguo , Mark, Alan E. . 2555. "Molecular dynamics unlocks atomic level self-assembly of the exopolysaccharide matrix of water-treatment granular biofilms".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Seviour, Thomas , Malde, Alpeshkumar K. , Kjelleberg, Staffan , Yuan, Zhiguo , Mark, Alan E. . "Molecular dynamics unlocks atomic level self-assembly of the exopolysaccharide matrix of water-treatment granular biofilms."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Seviour, Thomas , Malde, Alpeshkumar K. , Kjelleberg, Staffan , Yuan, Zhiguo , Mark, Alan E. . Molecular dynamics unlocks atomic level self-assembly of the exopolysaccharide matrix of water-treatment granular biofilms. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.