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Diagnosis of Alzheimer's disease from EEG by means of synchrony measures in optimized frequency bands

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Diagnosis of Alzheimer's disease from EEG by means of synchrony measures in optimized frequency bands
นักวิจัย : Gallego-Jutglà, Esteve , Elgendi, Mohamed , Vialatte, François-Benoît , Solé-Casals, Jordi , Cichocki, Andrzej , Latchoumane, Charles , Jeong, Jaeseung , Dauwels, Justin
คำค้น : DRNTU::Engineering::Electrical and electronic engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : http://hdl.handle.net/10220/12524 , http://dx.doi.org/10.1109/EMBC.2012.6346909
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Several clinical studies have reported that EEG synchrony is affected by Alzheimer's disease (AD). In this paper a frequency band analysis of AD EEG signals is presented, with the aim of improving the diagnosis of AD using EEG signals. In this paper, multiple synchrony measures are assessed through statistical tests (Mann-Whitney U test), including correlation, phase synchrony and Granger causality measures. Moreover, linear discriminant analysis (LDA) is conducted with those synchrony measures as features. For the data set at hand, the frequency range (5-6Hz) yields the best accuracy for diagnosing AD, which lies within the classical theta band (4-8Hz). The corresponding classification error is 4.88% for directed transfer function (DTF) Granger causality measure. Interestingly, results show that EEG of AD patients is more synchronous than in healthy subjects within the optimized range 5-6Hz, which is in sharp contrast with the loss of synchrony in AD EEG reported in many earlier studies. This new finding may provide new insights about the neurophysiology of AD. Additional testing on larger AD datasets is required to verify the effectiveness of the proposed approach.

บรรณานุกรม :
Gallego-Jutglà, Esteve , Elgendi, Mohamed , Vialatte, François-Benoît , Solé-Casals, Jordi , Cichocki, Andrzej , Latchoumane, Charles , Jeong, Jaeseung , Dauwels, Justin . (2555). Diagnosis of Alzheimer's disease from EEG by means of synchrony measures in optimized frequency bands.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Gallego-Jutglà, Esteve , Elgendi, Mohamed , Vialatte, François-Benoît , Solé-Casals, Jordi , Cichocki, Andrzej , Latchoumane, Charles , Jeong, Jaeseung , Dauwels, Justin . 2555. "Diagnosis of Alzheimer's disease from EEG by means of synchrony measures in optimized frequency bands".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Gallego-Jutglà, Esteve , Elgendi, Mohamed , Vialatte, François-Benoît , Solé-Casals, Jordi , Cichocki, Andrzej , Latchoumane, Charles , Jeong, Jaeseung , Dauwels, Justin . "Diagnosis of Alzheimer's disease from EEG by means of synchrony measures in optimized frequency bands."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Gallego-Jutglà, Esteve , Elgendi, Mohamed , Vialatte, François-Benoît , Solé-Casals, Jordi , Cichocki, Andrzej , Latchoumane, Charles , Jeong, Jaeseung , Dauwels, Justin . Diagnosis of Alzheimer's disease from EEG by means of synchrony measures in optimized frequency bands. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.