ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

The effect of osteochondral regeneration using polymer constructs and continuous passive motion therapy in the lower weight-bearing zone of femoral trocheal groove in rabbits

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : The effect of osteochondral regeneration using polymer constructs and continuous passive motion therapy in the lower weight-bearing zone of femoral trocheal groove in rabbits
นักวิจัย : Chang, Nai-Jen , Lin, Chih-Chan , Li, Chien-Feng , Su, Kai , Yeh, Ming-Long
คำค้น : DRNTU::Engineering::Chemical engineering::Biotechnology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Chang, N.-J., Lin, C.-C., Li, C.-F., Su, K., & Yeh, M.-L. (2013). The Effect of Osteochondral Regeneration Using Polymer Constructs and Continuous Passive Motion Therapy in the Lower Weight-Bearing Zone of Femoral Trocheal Groove in Rabbits. Annals of Biomedical Engineering, 41(2), 385-397. , 0090-6964 , http://hdl.handle.net/10220/12509 , http://dx.doi.org/10.1007/s10439-012-0656-7
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Annals of biomedical engineering
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Remedying patellofemoral osteochondral defects using clinical therapy remains challenging. Construct-based and cell-based regenerative medicine with in vitro physical stimuli has been progressively implemented. However, the effect of physical stimuli in situ in knee joints with degradable constructs is still not well-documented. Therefore, we studied whether it was practical to achieve articular cartilage repair using a poly(lactic-co-glycolic acid) (PLGA) construct in addition to early short-term continuous passive motion (CPM) for treatment of full-thickness osteochondral defects in the lower-weigh bearing (LWB) zone of the femoral trocheal groove. Twenty-six rabbits were randomly allocated into either intermittent active motion (IAM) or CPM treatment groups with or without PLGA constructs, termed PLGA construct-implanted (PCI) and empty defect knee models, respectively. Gross observation, histology, inflammatory cells, which were identified using H&E staining, total collagen and alignment, studied qualitatively using Masson’s trichrome staining, glycosaminoglycan (GAG), identified using Alcian blue staining, and newly formed bone, observed using micro-CT, were evaluated at 4 and 12 weeks after surgery. Repair of osteochondral defects in the PCI-CPM group was more promising than all other groups. The better osteochondral defect repair in the PCI-CPM group corresponded to smooth cartilage surfaces, no inflammatory reaction, hyaline cartilaginous tissues composition, sound collagen alignment with positive collagen type II expression, higher GAG content, mature bone regeneration with osteocyte, clear tidemark formation, and better degradation of PLGA. In summary, the use of a simple PLGA construct coupled with passive motion promotes positive healing and may be a promising clinical intervention for osteochondral regeneration in LWB defects.

บรรณานุกรม :
Chang, Nai-Jen , Lin, Chih-Chan , Li, Chien-Feng , Su, Kai , Yeh, Ming-Long . (2555). The effect of osteochondral regeneration using polymer constructs and continuous passive motion therapy in the lower weight-bearing zone of femoral trocheal groove in rabbits.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chang, Nai-Jen , Lin, Chih-Chan , Li, Chien-Feng , Su, Kai , Yeh, Ming-Long . 2555. "The effect of osteochondral regeneration using polymer constructs and continuous passive motion therapy in the lower weight-bearing zone of femoral trocheal groove in rabbits".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chang, Nai-Jen , Lin, Chih-Chan , Li, Chien-Feng , Su, Kai , Yeh, Ming-Long . "The effect of osteochondral regeneration using polymer constructs and continuous passive motion therapy in the lower weight-bearing zone of femoral trocheal groove in rabbits."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Chang, Nai-Jen , Lin, Chih-Chan , Li, Chien-Feng , Su, Kai , Yeh, Ming-Long . The effect of osteochondral regeneration using polymer constructs and continuous passive motion therapy in the lower weight-bearing zone of femoral trocheal groove in rabbits. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.