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Advanced immobilization and amplification for high performance protein chips.

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Advanced immobilization and amplification for high performance protein chips.
นักวิจัย : Liu, Yingshuai. , Li, Chang Ming.
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Liu, Y., & Li, C. M. (2012). Advanced Immobilization and Amplification for High Performance Protein Chips. Analytical Letters, 45(2-3), 130-155. , http://hdl.handle.net/10220/12433 , http://dx.doi.org/10.1080/00032719.2011.633187
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Analytical letters
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

With the success of high-throughput DNA microarrays, protein biochips have been intensively investigated and broadly used in bioscience research, clinic diagnosis, drug discovery, and other applications. However, there is great need to significantly improve the sensitivity of protein chips, especially in early diagnosis. A major challenge of improving sensitivity is that protein detection does not have an effective amplification method, such as PCR for DNA microarrays. Construction of unique biofilms for efficient immobilization of protein probes and innovation of new amplification schemes could play a critical role in performance improvement of protein biochips. With dramatic developments in microfabrication, nanotechnologies, and biotechnologies, enormous progress has been made, particularly in improving biosensing sensitivity. This article reviews new advances in protein biochip technologies with emphasis on novel approaches for efficient probe immobilization and nanomaterials-assisted signal amplification for high performance protein chips. Prominent progress in integration of protein microarrays with microfluidic platforms is briefly discussed. The major challenges and perspectives on the future of protein biochips are also addressed.

บรรณานุกรม :
Liu, Yingshuai. , Li, Chang Ming. . (2555). Advanced immobilization and amplification for high performance protein chips..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liu, Yingshuai. , Li, Chang Ming. . 2555. "Advanced immobilization and amplification for high performance protein chips.".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liu, Yingshuai. , Li, Chang Ming. . "Advanced immobilization and amplification for high performance protein chips.."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Liu, Yingshuai. , Li, Chang Ming. . Advanced immobilization and amplification for high performance protein chips.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.