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In-vivo evaluation of an in situ polymer precipitation delivery system for a novel natriuretic peptide

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : In-vivo evaluation of an in situ polymer precipitation delivery system for a novel natriuretic peptide
นักวิจัย : Lim, Soo Ghim , Venkatraman, Subbu S. , Burnett Jr, John C. , Chen, Horng H.
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Lim, S. G., Venkatraman, S. S., Burnett Jr, J. C., & Chen, H. H. (2013). In-Vivo Evaluation of an In Situ Polymer Precipitation Delivery System for a Novel Natriuretic Peptide. PLoS ONE, 8(2), e52484. , 1932-6203 , http://hdl.handle.net/10220/11906 , http://dx.doi.org/10.1371/journal.pone.0052484 , 171886
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : PLoS One
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

This study reports on the release of a novel natriuretic peptide, CD-NP, from an in situ polymer precipitation delivery system. Following extensive screening of in-vitro release profiles, an in-vivo evaluation of the efficacy of the delivery system was carried out in Wistar rats. Gel injection was performed subcutaneously on the back of the rats. A secondary messenger, cyclic Guanosine 3′5′ Monophosphate (cGMP), was tested for verification of CD-NP bioactivity, in addition to direct measurements of CD-NP levels in plasma and urine using a radio-immuno assay. Plasma evaluation showed an elevated level of CD-NP over 3 weeks' duration. Unexpectedly, plasma cGMP level followed a decreasing trend over the same duration despite high CD-NP level. Loss of drug bioactivity was ruled out as a high level of CD-NP and cGMP excretion was observed in the treatment group as compared to baseline readings. This unexpected low-plasma cGMP levels and high-urinary cGMP excretion suggest that there might be other compensatory responses to regulation of the CDNP bioactivity as a result of the high drug dosing. The results stress the importance of assessing the overall bioactivity of released drug (in-vivo) concurrently in addition to measuring its concentrations, to determine the correct release profile.

บรรณานุกรม :
Lim, Soo Ghim , Venkatraman, Subbu S. , Burnett Jr, John C. , Chen, Horng H. . (2556). In-vivo evaluation of an in situ polymer precipitation delivery system for a novel natriuretic peptide.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lim, Soo Ghim , Venkatraman, Subbu S. , Burnett Jr, John C. , Chen, Horng H. . 2556. "In-vivo evaluation of an in situ polymer precipitation delivery system for a novel natriuretic peptide".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lim, Soo Ghim , Venkatraman, Subbu S. , Burnett Jr, John C. , Chen, Horng H. . "In-vivo evaluation of an in situ polymer precipitation delivery system for a novel natriuretic peptide."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Lim, Soo Ghim , Venkatraman, Subbu S. , Burnett Jr, John C. , Chen, Horng H. . In-vivo evaluation of an in situ polymer precipitation delivery system for a novel natriuretic peptide. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.