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Gene silencing of human neuronal cells for drug addiction therapy using anisotropic nanocrystals

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Gene silencing of human neuronal cells for drug addiction therapy using anisotropic nanocrystals
นักวิจัย : Law, Wing-Cheung , Mahajan, Supriya D. , Kopwitthaya, Atcha , Reynolds, Jessica L. , Liu, Maixian , Liu, Xin , Chen, Guanying , Erogbogbo, Folarin , Vathy, Lisa , Aalinkeel, Ravikumar , Schwartz, Stanley A. , Yong, Ken-Tye , Prasad, Paras N.
คำค้น : DRNTU::Engineering::Electrical and electronic engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Law, W.-C., Mahajan, S. D., Kopwitthaya, A., Reynolds, J. L., Liu, M., Liu, X., et al. (2012). Gene Silencing of Human Neuronal Cells for Drug Addiction Therapy using Anisotropic Nanocrystals. Theranostics, 2(7), 695-704. , 1838-7640 , http://hdl.handle.net/10220/11858 , http://dx.doi.org/10.7150/thno.3459
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Theranostics
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Theranostic platform integrating diagnostic imaging and therapeutic function into a single system has become a new direction of nanoparticle research. In the process of treatment, therapeutic efficacy is monitored. The use of theranostic nanoparticle can add an additional "layer" to keep track on the therapeutic agent such as the pharmacokinetics and biodistribution. In this report, we have developed quantum rod (QR) based formulations for the delivery of small interfering RNAs (siRNAs) to human neuronal cells. PEGlyated QRs with different surface functional groups (amine and maleimide) were designed for selectively down-regulating the dopaminergic signaling pathway which is associated with the drug abuse behavior. We have demonstrated that the DARPP-32 siRNAs were successfully delivered to dopaminergic neuronal (DAN) cells which led to drastic knockdown of specific gene expression by both the electrostatic and covalent bond conjugation regimes. The PEGlyated surface offered high biocompatibilities and negligible cytotoxicities to the QR formulations that may facilitate the in vivo applications of these nanoparticles.

บรรณานุกรม :
Law, Wing-Cheung , Mahajan, Supriya D. , Kopwitthaya, Atcha , Reynolds, Jessica L. , Liu, Maixian , Liu, Xin , Chen, Guanying , Erogbogbo, Folarin , Vathy, Lisa , Aalinkeel, Ravikumar , Schwartz, Stanley A. , Yong, Ken-Tye , Prasad, Paras N. . (2555). Gene silencing of human neuronal cells for drug addiction therapy using anisotropic nanocrystals.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Law, Wing-Cheung , Mahajan, Supriya D. , Kopwitthaya, Atcha , Reynolds, Jessica L. , Liu, Maixian , Liu, Xin , Chen, Guanying , Erogbogbo, Folarin , Vathy, Lisa , Aalinkeel, Ravikumar , Schwartz, Stanley A. , Yong, Ken-Tye , Prasad, Paras N. . 2555. "Gene silencing of human neuronal cells for drug addiction therapy using anisotropic nanocrystals".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Law, Wing-Cheung , Mahajan, Supriya D. , Kopwitthaya, Atcha , Reynolds, Jessica L. , Liu, Maixian , Liu, Xin , Chen, Guanying , Erogbogbo, Folarin , Vathy, Lisa , Aalinkeel, Ravikumar , Schwartz, Stanley A. , Yong, Ken-Tye , Prasad, Paras N. . "Gene silencing of human neuronal cells for drug addiction therapy using anisotropic nanocrystals."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Law, Wing-Cheung , Mahajan, Supriya D. , Kopwitthaya, Atcha , Reynolds, Jessica L. , Liu, Maixian , Liu, Xin , Chen, Guanying , Erogbogbo, Folarin , Vathy, Lisa , Aalinkeel, Ravikumar , Schwartz, Stanley A. , Yong, Ken-Tye , Prasad, Paras N. . Gene silencing of human neuronal cells for drug addiction therapy using anisotropic nanocrystals. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.