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Synthesis and cytocompatibility of manganese (II) and iron (III) substituted hydroxyapatite nanoparticles

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Synthesis and cytocompatibility of manganese (II) and iron (III) substituted hydroxyapatite nanoparticles
นักวิจัย : Li, Yan , Widodo, Jasmine , Lim, Sierin , Ooi, Chui Ping
คำค้น : DRNTU::Engineering::Chemical engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2554
อ้างอิง : Li, Y., Widodo, J., Lim, S., & Ooi, C. P. (2012). Synthesis and cytocompatibility of manganese (II) and iron (III) substituted hydroxyapatite nanoparticles. Journal of Materials Science, 47(2), 754-763. , http://hdl.handle.net/10220/11596 , http://dx.doi.org/10.1007/s10853-011-5851-7
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of materials science
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Manganese (II) and iron (III) substituted hydroxyapatite (HA, Ca10(PO4)6(OH)2) nanoparticles were synthesized using wet chemical method. All samples were single-phase, non-stoichiometric and B-type carbonated hydroxyapatite. Compared with pure HA, Mn2+ substituted (MnHA) and Fe3+ doped HA (FeHA) did not demonstrate significant structure deviation. Since ion exchange mechanism was applied for the synthesis process, the morphology and particle size were not significantly affected: all samples were elongated spheroids of around 70 nm. The presence of Fe and Mn was confirmed by energy dispersive X-ray spectroscopy (EDX) while the concentrations were quantified by inductively coupled plasma (ICP). Fe3+ ions were more active than Mn2+ ions in replacing Ca2+ ions in HA lattice structure. The magnetic property of HA was modified by substitution with Fe. The Fe5 (Feadded/Caadded = 5% by molar ratio) was paramagnetic while pure HA was diamagnetic. Results of extraction assay from cells cultured in extracted medium for 72 h suggested that both MnHA and FeHA were non-cytotoxic to osteoblast cells. Meanwhile, the presence of Fe3+ ions in HA demonstrated significant positive effect on osteoblast cells, where the cell number on Fe5 pellets was twice that of pure HA and MnHA samples.

บรรณานุกรม :
Li, Yan , Widodo, Jasmine , Lim, Sierin , Ooi, Chui Ping . (2554). Synthesis and cytocompatibility of manganese (II) and iron (III) substituted hydroxyapatite nanoparticles.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Li, Yan , Widodo, Jasmine , Lim, Sierin , Ooi, Chui Ping . 2554. "Synthesis and cytocompatibility of manganese (II) and iron (III) substituted hydroxyapatite nanoparticles".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Li, Yan , Widodo, Jasmine , Lim, Sierin , Ooi, Chui Ping . "Synthesis and cytocompatibility of manganese (II) and iron (III) substituted hydroxyapatite nanoparticles."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2554. Print.
Li, Yan , Widodo, Jasmine , Lim, Sierin , Ooi, Chui Ping . Synthesis and cytocompatibility of manganese (II) and iron (III) substituted hydroxyapatite nanoparticles. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2554.