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Designing calcium phosphate-based bifunctional nanocapsules with bone-targeting properties

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Designing calcium phosphate-based bifunctional nanocapsules with bone-targeting properties
นักวิจัย : Khung, Yit-Lung , Bastari, Kelsen , Cho, Xing Ling , Yee, Wu Aik , Loo, Say Chye Joachim
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Khung, Y. L., Bastari, K., Cho, X. L., Yee, W. A., & Loo, S. C. J. (2012). Designing calcium phosphate-based bifunctional nanocapsules with bone-targeting properties. Journal of nanoparticle research, 14(6). , 1572-896X , http://hdl.handle.net/10220/11453 , http://dx.doi.org/10.1007/s11051-012-0911-8
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of nanoparticle research
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Using sodium dodecyl sulphate micelles as template, hollow-cored calcium phosphate nanocapsules were produced. The surfaces of the nanocapsule were subsequently silanised by a polyethylene glycol (PEG)-based silane with an N-hydroxysuccinimide ester end groups which permits for further attachment with bisphosphonates (BP). Characterisations of these nanocapsules were investigated using Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy, Fourier Transform Infra-Red Spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy and Dynamic Light Scattering. To further validate the bone-targeting potential, dentine discs were incubated with these functionalised nanocapsules. FESEM analysis showed that these surface-modified nanocapsules would bind strongly to dentine surfaces compared to non-functionalised nanocapsules. We envisage that respective components would give this construct a bifunctional attribute, whereby (1) the shell of the calcium phosphate nanocapsule would serve as biocompatible coating aiding in gradual osteoconduction, while (2) surface BP moieties, acting as targeting ligands, would provide the bone-targeting potential of these calcium phosphate nanocapsules.

บรรณานุกรม :
Khung, Yit-Lung , Bastari, Kelsen , Cho, Xing Ling , Yee, Wu Aik , Loo, Say Chye Joachim . (2555). Designing calcium phosphate-based bifunctional nanocapsules with bone-targeting properties.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Khung, Yit-Lung , Bastari, Kelsen , Cho, Xing Ling , Yee, Wu Aik , Loo, Say Chye Joachim . 2555. "Designing calcium phosphate-based bifunctional nanocapsules with bone-targeting properties".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Khung, Yit-Lung , Bastari, Kelsen , Cho, Xing Ling , Yee, Wu Aik , Loo, Say Chye Joachim . "Designing calcium phosphate-based bifunctional nanocapsules with bone-targeting properties."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Khung, Yit-Lung , Bastari, Kelsen , Cho, Xing Ling , Yee, Wu Aik , Loo, Say Chye Joachim . Designing calcium phosphate-based bifunctional nanocapsules with bone-targeting properties. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.