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Dual-window dual-bandwidth spectroscopic optical coherence tomography metric for qualitative scatterer size differentiation in tissues

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Dual-window dual-bandwidth spectroscopic optical coherence tomography metric for qualitative scatterer size differentiation in tissues
นักวิจัย : Tay, Benjamin Chia Meng , Chow, Tzu-Hao , Ng, Beng-Koon , Loh, Thomas Kwok-Seng
คำค้น : DRNTU::Engineering::Electrical and electronic engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Tay, B. C. M., Chow, T. H., Ng, B. K., & Loh, T. K. S. (2012). Dual-window dual-bandwidth spectroscopic optical coherence tomography metric for qualitative scatterer size differentiation in tissues. IEEE Transactions on Biomedical Engineering, 59(9), 2439-2448. , 0018-9294 , http://hdl.handle.net/10220/11323 , http://dx.doi.org/10.1109/TBME.2012.2202391
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : IEEE transactions on biomedical engineering
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

This study investigates the autocorrelation bandwidths of dual-window (DW) optical coherence tomography (OCT) k-space scattering profile of different-sized microspheres and their correlation to scatterer size. A dual-bandwidth spectroscopic metric defined as the ratio of the 10% to 90% autocorrelation bandwidths is found to change monotonically with microsphere size and gives the best contrast enhancement for scatterer size differentiation in the resulting spectroscopic image. A simulation model supports the experimental results and revealed a tradeoff between the smallest detectable scatterer size and the maximum scatterer size in the linear range of the dual-window dual-bandwidth (DWDB) metric, which depends on the choice of the light source optical bandwidth. Spectroscopic OCT (SOCT) images of microspheres and tonsil tissue samples based on the proposed DWDB metric showed clear differentiation between different-sized scatterers as compared to those derived from conventional short-time Fourier transform metrics. The DWDB metric significantly improves the contrast in SOCT imaging and can aid the visualization and identification of dissimilar scatterer size in a sample. Potential applications include the early detection of cell nuclear changes in tissue carcinogenesis, the monitoring of healing tendons, and cell proliferation in tissue scaffolds.

บรรณานุกรม :
Tay, Benjamin Chia Meng , Chow, Tzu-Hao , Ng, Beng-Koon , Loh, Thomas Kwok-Seng . (2555). Dual-window dual-bandwidth spectroscopic optical coherence tomography metric for qualitative scatterer size differentiation in tissues.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tay, Benjamin Chia Meng , Chow, Tzu-Hao , Ng, Beng-Koon , Loh, Thomas Kwok-Seng . 2555. "Dual-window dual-bandwidth spectroscopic optical coherence tomography metric for qualitative scatterer size differentiation in tissues".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tay, Benjamin Chia Meng , Chow, Tzu-Hao , Ng, Beng-Koon , Loh, Thomas Kwok-Seng . "Dual-window dual-bandwidth spectroscopic optical coherence tomography metric for qualitative scatterer size differentiation in tissues."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Tay, Benjamin Chia Meng , Chow, Tzu-Hao , Ng, Beng-Koon , Loh, Thomas Kwok-Seng . Dual-window dual-bandwidth spectroscopic optical coherence tomography metric for qualitative scatterer size differentiation in tissues. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.