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Apelin inhibits adipogenesis and lipolysis through distint molecular pathways

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Apelin inhibits adipogenesis and lipolysis through distint molecular pathways
นักวิจัย : Than, Aung , Cheng, Yiqi , Foh, Li-Chern , Leow, Melvin Khee-Shing , Lim, Su Chi , Chuah, Yon Jin , Kang, Yuejun , Chen, Peng
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Than, A., Cheng, Y., Foh, L.-C., Leow, M. K.-S., Lim, S. C., Chuah, Y. J., et al. (2012). Apelin inhibits adipogenesis and lipolysis through distint molecular pathways. Molecular and Cellular Endocrinology, 362(1-2), 227-241. , http://hdl.handle.net/10220/11157 , http://dx.doi.org/10.1016/j.mce.2012.07.002
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Molecular and cellular endocrinology
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Apelin is an adipokine secreted by adipocytes. Co-expression of apelin and apelin receptor (APJ) in adipocytes implies the autocrine regulations of apelin on adipocyte functions through yet unknown molecular mechanisms. In the present study, we provide evidence that apelin, through its interaction with APJ receptor, inhibits adipogenesis of pre-adipocytes and lipolysis in mature adipocytes. The detailed molecular pathways underlying apelin signaling is proposed based on our experimental observations. Specifically, we show that apelin suppresses adipogenesis through MAPK kinase/ERK dependent pathways. And by preventing lipid droplet fragmentation, apelin inhibits basal lipolysis through AMP kinase dependent enhancement of perilipin expression and inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induced decrease of free fatty acid release can be attributed to its dual inhibition on adipogenesis and lipolysis. This study suggests that the autocrine signaling of apelin may serve as a novel therapeutic target for obesity and other metabolic disorders.

บรรณานุกรม :
Than, Aung , Cheng, Yiqi , Foh, Li-Chern , Leow, Melvin Khee-Shing , Lim, Su Chi , Chuah, Yon Jin , Kang, Yuejun , Chen, Peng . (2555). Apelin inhibits adipogenesis and lipolysis through distint molecular pathways.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Than, Aung , Cheng, Yiqi , Foh, Li-Chern , Leow, Melvin Khee-Shing , Lim, Su Chi , Chuah, Yon Jin , Kang, Yuejun , Chen, Peng . 2555. "Apelin inhibits adipogenesis and lipolysis through distint molecular pathways".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Than, Aung , Cheng, Yiqi , Foh, Li-Chern , Leow, Melvin Khee-Shing , Lim, Su Chi , Chuah, Yon Jin , Kang, Yuejun , Chen, Peng . "Apelin inhibits adipogenesis and lipolysis through distint molecular pathways."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Than, Aung , Cheng, Yiqi , Foh, Li-Chern , Leow, Melvin Khee-Shing , Lim, Su Chi , Chuah, Yon Jin , Kang, Yuejun , Chen, Peng . Apelin inhibits adipogenesis and lipolysis through distint molecular pathways. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.