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Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors
นักวิจัย : Than, Aung , Tee, Wei Teng , Chen, Peng
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Than, A., Tee, W. T., Chen, P. (2012). Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors. Molecular and Cellular Endocrinology, 351(2), 296-305. , http://hdl.handle.net/10220/11154 , http://dx.doi.org/10.1016/j.mce.2012.01.005
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Molecular and cellular endocrinology
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Adipocytes play pivotal roles in regulating metabolism through secretion of a variety of adipokines, which in turn is regulated by other metabolic factors (e.g., insulin). Understanding the regulations of adipokine secretion is important because adipokines are implicated with metabolic disorders, such as, obesity and diabetes mellitus. Here, we investigated the regulatory roles of angiotensin II (AngII) on the secretion of apelin in 3T3-L1 adipocytes, and distinct signaling pathways mediated by AngII receptor type 1 (AT1) and type 2 (AT2) were revealed. It was found that activation of AT1 receptors stimulates apelin secretion in Ca2+, protein kinase C, and MAPK kinase dependent ways while activation of AT2 receptors inhibits apelin secretion through cAMP and cGMP dependent pathways. Furthermore, we demonstrate that the expression of apelin receptor (APJ) is also similarly regulated by AT1 and AT2 receptors. Finally, a detailed AngII signaling map is proposed.

บรรณานุกรม :
Than, Aung , Tee, Wei Teng , Chen, Peng . (2555). Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Than, Aung , Tee, Wei Teng , Chen, Peng . 2555. "Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Than, Aung , Tee, Wei Teng , Chen, Peng . "Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Than, Aung , Tee, Wei Teng , Chen, Peng . Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.