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Single cell analysis at the nanoscale.

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Single cell analysis at the nanoscale.
นักวิจัย : Zheng, Xin Ting. , Li, Chang Ming.
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Zheng, X. T., Li, C. M. (2012). Single cell analysis at the nanoscale. Chemical Society Reviews, 41(6), 2061-2071. , http://hdl.handle.net/10220/11160 , http://dx.doi.org/10.1039/c1cs15265c
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Chemical society reviews
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The fundamental life processes such as signal transduction, intracellular trafficking, protein degradation, and DNA repair often occur in nanometric subcellular compartments. It is essential to conduct single cell analysis specifically at the nanoscale to fully understand the critical cellular processes while providing important medical applications. However, there are great challenges in achieving high spatial resolution in single cells for uncovering spatial heterogeneity, high sensitivity for biomolecule detections and high specificity in complicated cellular environment. In this tutorial review, we survey recent progress toward single cell analysis at the nanoscale by emphasizing how the advancement in nanotechnology has brought a plethora of nanotools to interrogate single cells with high spatiotemporal resolutions. In particular, analysis principle, nanoscale probe fabrication, high resolution cellular analysis, data collection and processing are introduced. New cell biochemistry and biology insights revealed by the unique single cell analysis methods are highlighted. The perspectives on future opportunities and unsolved challenges are also discussed.

บรรณานุกรม :
Zheng, Xin Ting. , Li, Chang Ming. . (2555). Single cell analysis at the nanoscale..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zheng, Xin Ting. , Li, Chang Ming. . 2555. "Single cell analysis at the nanoscale.".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zheng, Xin Ting. , Li, Chang Ming. . "Single cell analysis at the nanoscale.."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Zheng, Xin Ting. , Li, Chang Ming. . Single cell analysis at the nanoscale.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.