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RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors
นักวิจัย : Chuang, Linda Shyue Huey , Lai, Soak Kuan , Murata-Hori, Maki , Yamada, Ayumi , Li, Hoi-Yeung , Gunaratne, Jayantha , Ito, Yoshiaki
คำค้น : DRNTU::Science::Biological sciences
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Chuang, L. S. H., Lai, S. K., Murata-Hori, M., Yamada, A., Li, H.-Y., Gunaratne, J., et al. (2012). RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors. Cell Cycle, 11(10), 1938-1947. , http://hdl.handle.net/10220/11093 , http://dx.doi.org/10.4161/cc.20278
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Cell cycle
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

RUNX family proteins are critical regulators of lineage differentiation during development. The high prevalence of RUNX mutation/epigenetic inactivation in human cancer indicates a causative role for dysfunctional RUNX in carcinogenesis. This is supported by well-documented evidence of functional interaction of RUNX with components of major oncogenic or tumor suppressive signaling pathways such as TGFβ and Wnt. Here, we explore the binding partners of RUNX3 proteins to further define the scope of RUNX3 function. Using a mass spectrometry-based approach, we found that RUNX3 binds to centrosomal protein rootletin. This led us to uncover the presence of RUNX proteins at the centrosome. Our findings suggest a potential function for RUNX3 during mitosis.

บรรณานุกรม :
Chuang, Linda Shyue Huey , Lai, Soak Kuan , Murata-Hori, Maki , Yamada, Ayumi , Li, Hoi-Yeung , Gunaratne, Jayantha , Ito, Yoshiaki . (2555). RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chuang, Linda Shyue Huey , Lai, Soak Kuan , Murata-Hori, Maki , Yamada, Ayumi , Li, Hoi-Yeung , Gunaratne, Jayantha , Ito, Yoshiaki . 2555. "RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chuang, Linda Shyue Huey , Lai, Soak Kuan , Murata-Hori, Maki , Yamada, Ayumi , Li, Hoi-Yeung , Gunaratne, Jayantha , Ito, Yoshiaki . "RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Chuang, Linda Shyue Huey , Lai, Soak Kuan , Murata-Hori, Maki , Yamada, Ayumi , Li, Hoi-Yeung , Gunaratne, Jayantha , Ito, Yoshiaki . RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.