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The toxicity of amyloid ß oligomers

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : The toxicity of amyloid ß oligomers
นักวิจัย : Zhao, Li Na , Long, Hon Wai , Mu, Yuguang , Chew, Lock Yue
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Zhao, L. N., Long, H. W., Mu, Y., & Chew, L. Y. (2012). The Toxicity of Amyloid ß Oligomers. International Journal of Molecular Sciences, 13(6), 7303-7327. , 1422-0067 , http://hdl.handle.net/10220/11059 , http://dx.doi.org/10.3390/ijms13067303
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : International journal of molecular sciences
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

In this review, we elucidate the mechanisms of Aβ oligomer toxicity which may contribute to Alzheimer’s disease (AD). In particular, we discuss on the interaction of Aβ oligomers with the membrane through the process of adsorption and insertion. Such interaction gives rises to phase transitions in the sub-structures of the Aβ peptide from α-helical to β-sheet structure. By means of a coarse-grained model, we exhibit the tendency of β-sheet structures to aggregate, thus providing further insights to the process of membrane induced aggregation. We show that the aggregated oligomer causes membrane invagination, which is a precursor to the formation of pore structures and ion channels. Other pathological progressions to AD due to Aβ oligomers are also covered, such as their interaction with the membrane receptors, and their direct versus indirect effects on oxidative stress and intraneuronal accumulation. We further illustrate that the molecule curcumin is a potential Aβ toxicity inhibitor as a β-sheet breaker by having a high propensity to interact with certain Aβ residues without binding to them. The comprehensive understanding gained from these current researches on the various toxicity mechanisms show promises in the provision of better therapeutics and treatment strategies in the near future.

บรรณานุกรม :
Zhao, Li Na , Long, Hon Wai , Mu, Yuguang , Chew, Lock Yue . (2555). The toxicity of amyloid ß oligomers.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhao, Li Na , Long, Hon Wai , Mu, Yuguang , Chew, Lock Yue . 2555. "The toxicity of amyloid ß oligomers".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhao, Li Na , Long, Hon Wai , Mu, Yuguang , Chew, Lock Yue . "The toxicity of amyloid ß oligomers."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Zhao, Li Na , Long, Hon Wai , Mu, Yuguang , Chew, Lock Yue . The toxicity of amyloid ß oligomers. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.