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Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice
นักวิจัย : Guo, Ke , Tang, Jing Ping , Jie, Li , Al-Aidaroos, Abdul Qader O. , Hong, Cheng William , Tan, Cheng Peow Bobby , Park, Jung Eun , Varghese, Leyon , Feng, Zhiwei , Zhou, Jianbiao , Chng, Wee Joo , Zeng, Qi
คำค้น : DRNTU::Science::Biological sciences
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Guo, K., Tang, J. P., Jie, L., Al-Aidaroos, A. Q. O., Hong, C. W., Tan, C. P. B., et al. (2012). Engineering the First Chimeric Antibody in Targeting Intracellular PRL-3 Oncoprotein for Cancer Therapy in Mice. Oncotarget, 3(2), 158-171. , 1949-2553 , http://hdl.handle.net/10220/10924 , http://www.ncbi.nlm.nih.gov.ezlibproxy1.ntu.edu.sg/pmc/articles/PMC3326646/
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Oncotarget
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Antibodies are considered as ‘magic bullets’ because of their high specificity. It is believed that antibodies are too large to routinely enter the cytosol, thus antibody therapeutic approach has been limited to extracellular or secreted proteins expressed by cancer cells. However, many oncogenic proteins are localized within the cell. To explore the possibility of antibody therapies against intracellular targets, we generated a chimeric antibody targeting the intracellular PRL-3 oncoprotein to assess its antitumor activities in mice. Remarkably, we observed that the PRL-3 chimeric antibody could efficiently and specifically reduce the formation of PRL-3 expressing metastatic tumors. We further found that natural killer (NK) cells were important in mediating the therapeutic effect, which was only observed in a nude mouse model (T-cell deficient), but not in a Severe Combined Immunodeficiency’ (scid) mouse model (B- and T-cell deficient), indicating the anticancer effect also depends on host B-cell activity. Our study involving 377 nude and scid mice suggests that antibodies targeting intracellular proteins can be developed to treat cancer.

บรรณานุกรม :
Guo, Ke , Tang, Jing Ping , Jie, Li , Al-Aidaroos, Abdul Qader O. , Hong, Cheng William , Tan, Cheng Peow Bobby , Park, Jung Eun , Varghese, Leyon , Feng, Zhiwei , Zhou, Jianbiao , Chng, Wee Joo , Zeng, Qi . (2555). Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Guo, Ke , Tang, Jing Ping , Jie, Li , Al-Aidaroos, Abdul Qader O. , Hong, Cheng William , Tan, Cheng Peow Bobby , Park, Jung Eun , Varghese, Leyon , Feng, Zhiwei , Zhou, Jianbiao , Chng, Wee Joo , Zeng, Qi . 2555. "Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Guo, Ke , Tang, Jing Ping , Jie, Li , Al-Aidaroos, Abdul Qader O. , Hong, Cheng William , Tan, Cheng Peow Bobby , Park, Jung Eun , Varghese, Leyon , Feng, Zhiwei , Zhou, Jianbiao , Chng, Wee Joo , Zeng, Qi . "Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Guo, Ke , Tang, Jing Ping , Jie, Li , Al-Aidaroos, Abdul Qader O. , Hong, Cheng William , Tan, Cheng Peow Bobby , Park, Jung Eun , Varghese, Leyon , Feng, Zhiwei , Zhou, Jianbiao , Chng, Wee Joo , Zeng, Qi . Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.