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Ferrocenyl catechols : synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Ferrocenyl catechols : synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells
นักวิจัย : Tan, Kelvin Yong Leng , Pigeon, Pascal , Top, Siden , Labbé, Eric , Buriez, Olivier , Hillard, Elizabeth A. , Vessières, Anne , Amatore, Christian , Leong, Weng Kee , Jaouen, Gérard
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Tan, K. Y. L., Pigeon, P., Top, S., Labbé, E., Buriez, O., Hillard, E. A., et al. (2012). Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells. Dalton Transactions, 41(25), 7537-7549. , 1477-9226 , http://hdl.handle.net/10220/10868 , http://dx.doi.org/10.1039/c2dt30700f
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Dalton transactions
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The synthesis and anti-tumoral properties of a series of compounds possessing a ferrocenyl group tethered to a catechol via a conjugated system is presented. On MDA-MB-231 breast cancer cell lines, the catechol compounds display a similar or greater anti-proliferative potency (IC50 values ranging from 0.48–1.21 μM) than their corresponding phenolic analogues (0.57–12.7 μM), with the highest activity found for species incorporating the [3]ferrocenophane motif. On the electrochemical timescale, phenolic compounds appear to oxidize to the quinone methide, while catechol moieties form the o-quinone by a similar mechanism. Chemical oxidation of selected compounds with Ag2O confirms this interpretation and demonstrates the probable involvement of such oxidative metabolites in the in vitro activity of these species.

บรรณานุกรม :
Tan, Kelvin Yong Leng , Pigeon, Pascal , Top, Siden , Labbé, Eric , Buriez, Olivier , Hillard, Elizabeth A. , Vessières, Anne , Amatore, Christian , Leong, Weng Kee , Jaouen, Gérard . (2555). Ferrocenyl catechols : synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tan, Kelvin Yong Leng , Pigeon, Pascal , Top, Siden , Labbé, Eric , Buriez, Olivier , Hillard, Elizabeth A. , Vessières, Anne , Amatore, Christian , Leong, Weng Kee , Jaouen, Gérard . 2555. "Ferrocenyl catechols : synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tan, Kelvin Yong Leng , Pigeon, Pascal , Top, Siden , Labbé, Eric , Buriez, Olivier , Hillard, Elizabeth A. , Vessières, Anne , Amatore, Christian , Leong, Weng Kee , Jaouen, Gérard . "Ferrocenyl catechols : synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Tan, Kelvin Yong Leng , Pigeon, Pascal , Top, Siden , Labbé, Eric , Buriez, Olivier , Hillard, Elizabeth A. , Vessières, Anne , Amatore, Christian , Leong, Weng Kee , Jaouen, Gérard . Ferrocenyl catechols : synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.