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Creating a living hyaline cartilage graft free from non-cartilaginous constituents : an intermediate role of a biomaterial scaffold

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Creating a living hyaline cartilage graft free from non-cartilaginous constituents : an intermediate role of a biomaterial scaffold
นักวิจัย : Su, Kai , Lau, Ting Ting , Leong, Wenyan , Gong, Yihong , Wang, Dong-An
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Su, K., Lau, T. T., Leong, W., Gong, Y., & Wang, D.-A. (2012). Creating a Living Hyaline Cartilage Graft Free from Non-Cartilaginous Constituents: An Intermediate Role of a Biomaterial Scaffold. Advanced Functional Materials, 22(5), 972-978. , 1616-3028 , http://hdl.handle.net/10220/10432 , http://dx.doi.org/10.1002/adfm.201102884
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Advanced functional materials
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A novel living hyaline cartilage graft (LhCG) with controllable dimensions and free of non-cartilaginous constituents for articular regeneration is developed. As a living graft for regenerative medicine, LhCG is purely living tissue based and truly scaffold-free. The process of neotissue formation in LhCG is mediated by an interim biomaterial-based novel scaffolding system. This design highlights a philosophy of using biomaterials in engineered regenerative medicine as a transient guiding facility rather than a permanent part of substitute. The fabrication is designed and practiced in a continuous and integrated process, which attributes to its simplicity in operation. Because of the intrinsic non-cell-adhesive property of hydrogel scaffolds, articular chondrocytes’ phenotype is always preserved throughout the whole procedure, which has been tested and approved both in vitro and in vivo. In situ grafting trials in a rabbit model showcase high success rates in both cartilage repair and graft-host integration. Beyond cartilage repair, this LhCG model may provide a living-tissue-based open platform or niche for multi-tissue regenerations.

บรรณานุกรม :
Su, Kai , Lau, Ting Ting , Leong, Wenyan , Gong, Yihong , Wang, Dong-An . (2555). Creating a living hyaline cartilage graft free from non-cartilaginous constituents : an intermediate role of a biomaterial scaffold.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Su, Kai , Lau, Ting Ting , Leong, Wenyan , Gong, Yihong , Wang, Dong-An . 2555. "Creating a living hyaline cartilage graft free from non-cartilaginous constituents : an intermediate role of a biomaterial scaffold".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Su, Kai , Lau, Ting Ting , Leong, Wenyan , Gong, Yihong , Wang, Dong-An . "Creating a living hyaline cartilage graft free from non-cartilaginous constituents : an intermediate role of a biomaterial scaffold."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Su, Kai , Lau, Ting Ting , Leong, Wenyan , Gong, Yihong , Wang, Dong-An . Creating a living hyaline cartilage graft free from non-cartilaginous constituents : an intermediate role of a biomaterial scaffold. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.