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Surface functionalization of nanoparticles to control cell interactions and drug release

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Surface functionalization of nanoparticles to control cell interactions and drug release
นักวิจัย : Luo, Rongcong , Neu, Björn , Venkatraman, Subbu S.
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Luo, R., Neu, B., & Venkatraman, S. S. (2012). Surface Functionalization of Nanoparticles to Control Cell Interactions and Drug Release. Small, 8(16), 2585-2594. , 1613-6810 , http://hdl.handle.net/10220/10390 , http://dx.doi.org/10.1002/smll.201200398
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Small
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Nanoparticles made from poly(dl-lactide-co-glycolide) (PLGA) are used to deliver a wide range of bioactive molecules, due to their biocompatibility and biodegradability. This study investigates the surface modification of PLGA nanoparticles via the layer-by-layer (LbL) deposition of polyelectrolytes, and the effects of these coatings on the release behavior, cytotoxicity, hemolytic activity, and cellular uptake efficiency. PLGA nanoparticles are modified via LbL adsorption of two polyelectrolyte pairs: 1) poly(allylamine hydrochloride) (PAH) and poly(styrene sulfonate) (PSS) and 2) poly(L-lysine hydrobromide) (PLL) and dextran sulfate (DES). It is demonstrated that both PAH/PSS and PLL/DES coatings suppress the burst release usually observed for unmodified PLGA nanoparticles and that the release behavior can be adjusted by changing the layer numbers, layer materials, or by crosslinking the layer constituents. Neither bare nor polyelectrolyte-modified PLGA nanoparticles show any signs of cytotoxicity. However, nanoparticles with a positively charged polyelectrolyte as the outermost layer induce hemolysis, whereas uncoated particles or particles with a negatively charged polyelectrolyte as the outermost layer show no hemolytic activity. Furthermore, particles with either PAH or PLL as the outermost layer also demonstrate a higher uptake efficiency by L929 fibroblast cells, due to a higher cell–particle affinity. This study suggests that LbL coating of PLGA nanoparticles can control the release behavior of bioactive molecules as well as the surface activity, therefore providing a promising strategy to enhance the efficiency of nanoparticulate drug-delivery systems.

บรรณานุกรม :
Luo, Rongcong , Neu, Björn , Venkatraman, Subbu S. . (2555). Surface functionalization of nanoparticles to control cell interactions and drug release.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Luo, Rongcong , Neu, Björn , Venkatraman, Subbu S. . 2555. "Surface functionalization of nanoparticles to control cell interactions and drug release".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Luo, Rongcong , Neu, Björn , Venkatraman, Subbu S. . "Surface functionalization of nanoparticles to control cell interactions and drug release."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Luo, Rongcong , Neu, Björn , Venkatraman, Subbu S. . Surface functionalization of nanoparticles to control cell interactions and drug release. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.