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Protein cage assisted metal-protein nanocomposite synthesis : optimization of loading conditions

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Protein cage assisted metal-protein nanocomposite synthesis : optimization of loading conditions
นักวิจัย : Sana, Barindra , Calista, Marcia , Lim, Sierin
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Sana, B., Calista, M., & Lim, S. (2012). Protein Cage Assisted Metal-Protein Nanocomposite Synthesis: Optimization of Loading Conditions. International Conference on Nanotechnology - Research and Commercialization 2011, 1502, pp. 82-96. , http://hdl.handle.net/10220/10087 , http://dx.doi.org/10.1063/1.4769136
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Ferritin is an iron-storage protein in most living systems with a cage-like structure. It has inherent property to form metallic nanocore within its cavity. The metallic core formed within the Archaeoglobus fulgidus ferritin cavity is stabilized by modulating the protein structure by site directed mutagenesis. Encapsulation protocol of various metals within the engineered ferritin cage (AfFtn-AA) is optimized. Dense metallic cores are visualized using electron microscopy and the bound metal was quantified by ICP-spectrometry. The AfFtn-AA is loaded with up to about 350 cobalt, 2000 chromium, and as high as 7000 iron atoms, separately. The metal-protein nanocomposites formed by encapsulation of cobalt, chromium, and iron are studied. Magnetic resonance imaging of the agarose embedded nanocomposites shows brightening of T1-weighted images and signal loss of T2-weighted images with increasing concentration of the nanocomposites. Shortening of magnetic relaxation times in the presence of the nanocomposites confirm their ability to enhance magnetic relaxation rate and suggests that the nanocomposites have potential application as MRI contrast agent.

บรรณานุกรม :
Sana, Barindra , Calista, Marcia , Lim, Sierin . (2555). Protein cage assisted metal-protein nanocomposite synthesis : optimization of loading conditions.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Sana, Barindra , Calista, Marcia , Lim, Sierin . 2555. "Protein cage assisted metal-protein nanocomposite synthesis : optimization of loading conditions".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Sana, Barindra , Calista, Marcia , Lim, Sierin . "Protein cage assisted metal-protein nanocomposite synthesis : optimization of loading conditions."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Sana, Barindra , Calista, Marcia , Lim, Sierin . Protein cage assisted metal-protein nanocomposite synthesis : optimization of loading conditions. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.