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Impedimetric immunoglobulin G immunosensor based on chemically modified graphenes

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Impedimetric immunoglobulin G immunosensor based on chemically modified graphenes
นักวิจัย : Loo, Adeline Huiling , Bonanni, Alessandra , Ambrosi, Adriano , Poh, Hwee Ling , Pumera, Martin
คำค้น : DRNTU::Engineering::Materials::Nanostructured materials.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Loo, A. H., Bonanni, A., Ambrosi, A., Poh, H. L., & Pumera, M. (2012). Impedimetric immunoglobulin G immunosensor based on chemically modified graphenes. Nanoscale, 4(3), 921-925. , http://hdl.handle.net/10220/10042 , http://dx.doi.org/10.1039/C2NR11492E , 165397
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Nanoscale
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Immunosensors which display high sensitivity and selectivity are of utmost importance to the biomedical field. Graphene is a material which has immense potential for the fabrication of immunosensors. For the first time, we evaluate the immunosensing capabilities of various graphene surfaces in this work. We propose a simple and label-free electrochemical impedimetric immunosensor for immunoglobulin G (IgG) based on chemically modified graphene (CMG) surfaces such as graphite oxide, graphene oxide, thermally reduced graphene oxide and electrochemically reduced graphene oxide. Disposable electrochemical printed electrodes were first modified with CMG materials before anti-immunoglobulin G (anti-IgG), which is specific to IgG, was immobilized. The principle of detection lies in the changes in impedance spectra of the redox probe after the attachment of IgG to the immobilized anti-IgG. It was found that thermally reduced graphene oxide has the best performance when compared to the other CMG materials. In addition, the optimal concentration of anti-IgG to be deposited onto the modified electrode surface is 10 μg ml−1 and the linear range of detection of the immunosensor is from 0.3 μg ml−1 to 7 μg ml−1. Finally, the fabricated immunosensor also displays selectivity for IgG.

บรรณานุกรม :
Loo, Adeline Huiling , Bonanni, Alessandra , Ambrosi, Adriano , Poh, Hwee Ling , Pumera, Martin . (2555). Impedimetric immunoglobulin G immunosensor based on chemically modified graphenes.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Loo, Adeline Huiling , Bonanni, Alessandra , Ambrosi, Adriano , Poh, Hwee Ling , Pumera, Martin . 2555. "Impedimetric immunoglobulin G immunosensor based on chemically modified graphenes".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Loo, Adeline Huiling , Bonanni, Alessandra , Ambrosi, Adriano , Poh, Hwee Ling , Pumera, Martin . "Impedimetric immunoglobulin G immunosensor based on chemically modified graphenes."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Loo, Adeline Huiling , Bonanni, Alessandra , Ambrosi, Adriano , Poh, Hwee Ling , Pumera, Martin . Impedimetric immunoglobulin G immunosensor based on chemically modified graphenes. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.