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Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells
นักวิจัย : Zhu, Pengcheng , Tong, Benny Meng Kiat , Wang, Runze , Chen, Jiapeng , Foo, Selin , Chong, Han Chung , Wang, Xiao Ling , Ang, Gim Yean , Chiba, Shunsuke , Tan, Nguan Soon
คำค้น : DRNTU::Science::Biological sciences::Microbiology.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Zhu, P., Tong, B. M. K., Wang, R., Chen, J. P., Foo, S., Chong, H. C., et al. (2013). Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells. Cell Death and Disease, 4, e552. , 2041-4889 , http://hdl.handle.net/10220/9452 , http://dx.doi.org/10.1038/cddis.2013.68 , 171102
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Cell death and disease
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Tumor metastasis is the main cause of death in cancer patients. Anoikis resistance is one critical malefactor of metastatic cancer cells to resist current clinical chemotherapeutic treatments. Although endoperoxide-containing compounds have long been suggested as anticancer drugs, few have been clinically employed due to their instability, complex synthesis procedure or low tumor cell selectivity. Herein, we describe a one-pot strategy to synthesize novel amino endoperoxides and their derivatives with good yields and stabilities. In vitro cell-based assays revealed that 4 out of the 14 amino endoperoxides selectively induce metastatic breast carcinoma cells but not normal breast cells to undergo apoptosis, in a dose-dependent manner. Mechanistic studies showed that the most potent amino endoperoxide, 4-Me, is selective for cancer cells expressing a high level of Nox4. The anticancer effects are further shown to be associated with reduced O2−:H2O2 ratio and increased ·OH level in the cancerous cells. Animal study showed that 4-Me impairs orthotopic breast tumor growth as well as tumor cell metastasis to lymph nodes. Altogether, our study suggests that anticancer strategies that focus on redox-based apoptosis induction in tumors are clinically viable.

บรรณานุกรม :
Zhu, Pengcheng , Tong, Benny Meng Kiat , Wang, Runze , Chen, Jiapeng , Foo, Selin , Chong, Han Chung , Wang, Xiao Ling , Ang, Gim Yean , Chiba, Shunsuke , Tan, Nguan Soon . (2556). Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhu, Pengcheng , Tong, Benny Meng Kiat , Wang, Runze , Chen, Jiapeng , Foo, Selin , Chong, Han Chung , Wang, Xiao Ling , Ang, Gim Yean , Chiba, Shunsuke , Tan, Nguan Soon . 2556. "Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhu, Pengcheng , Tong, Benny Meng Kiat , Wang, Runze , Chen, Jiapeng , Foo, Selin , Chong, Han Chung , Wang, Xiao Ling , Ang, Gim Yean , Chiba, Shunsuke , Tan, Nguan Soon . "Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Zhu, Pengcheng , Tong, Benny Meng Kiat , Wang, Runze , Chen, Jiapeng , Foo, Selin , Chong, Han Chung , Wang, Xiao Ling , Ang, Gim Yean , Chiba, Shunsuke , Tan, Nguan Soon . Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.