ชื่อเรื่อง | : | Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells |
นักวิจัย | : | Zhu, Pengcheng , Tong, Benny Meng Kiat , Wang, Runze , Chen, Jiapeng , Foo, Selin , Chong, Han Chung , Wang, Xiao Ling , Ang, Gim Yean , Chiba, Shunsuke , Tan, Nguan Soon |
คำค้น | : | DRNTU::Science::Biological sciences::Microbiology. |
หน่วยงาน | : | Nanyang Technological University, Singapore |
ผู้ร่วมงาน | : | - |
ปีพิมพ์ | : | 2556 |
อ้างอิง | : | Zhu, P., Tong, B. M. K., Wang, R., Chen, J. P., Foo, S., Chong, H. C., et al. (2013). Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells. Cell Death and Disease, 4, e552. , 2041-4889 , http://hdl.handle.net/10220/9452 , http://dx.doi.org/10.1038/cddis.2013.68 , 171102 |
ที่มา | : | - |
ความเชี่ยวชาญ | : | - |
ความสัมพันธ์ | : | Cell death and disease |
ขอบเขตของเนื้อหา | : | - |
บทคัดย่อ/คำอธิบาย | : | Tumor metastasis is the main cause of death in cancer patients. Anoikis resistance is one critical malefactor of metastatic cancer cells to resist current clinical chemotherapeutic treatments. Although endoperoxide-containing compounds have long been suggested as anticancer drugs, few have been clinically employed due to their instability, complex synthesis procedure or low tumor cell selectivity. Herein, we describe a one-pot strategy to synthesize novel amino endoperoxides and their derivatives with good yields and stabilities. In vitro cell-based assays revealed that 4 out of the 14 amino endoperoxides selectively induce metastatic breast carcinoma cells but not normal breast cells to undergo apoptosis, in a dose-dependent manner. Mechanistic studies showed that the most potent amino endoperoxide, 4-Me, is selective for cancer cells expressing a high level of Nox4. The anticancer effects are further shown to be associated with reduced O2−:H2O2 ratio and increased ·OH level in the cancerous cells. Animal study showed that 4-Me impairs orthotopic breast tumor growth as well as tumor cell metastasis to lymph nodes. Altogether, our study suggests that anticancer strategies that focus on redox-based apoptosis induction in tumors are clinically viable. |
บรรณานุกรม | : |
Zhu, Pengcheng , Tong, Benny Meng Kiat , Wang, Runze , Chen, Jiapeng , Foo, Selin , Chong, Han Chung , Wang, Xiao Ling , Ang, Gim Yean , Chiba, Shunsuke , Tan, Nguan Soon . (2556). Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhu, Pengcheng , Tong, Benny Meng Kiat , Wang, Runze , Chen, Jiapeng , Foo, Selin , Chong, Han Chung , Wang, Xiao Ling , Ang, Gim Yean , Chiba, Shunsuke , Tan, Nguan Soon . 2556. "Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhu, Pengcheng , Tong, Benny Meng Kiat , Wang, Runze , Chen, Jiapeng , Foo, Selin , Chong, Han Chung , Wang, Xiao Ling , Ang, Gim Yean , Chiba, Shunsuke , Tan, Nguan Soon . "Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print. Zhu, Pengcheng , Tong, Benny Meng Kiat , Wang, Runze , Chen, Jiapeng , Foo, Selin , Chong, Han Chung , Wang, Xiao Ling , Ang, Gim Yean , Chiba, Shunsuke , Tan, Nguan Soon . Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.
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