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Crystallization studies of the murine c-di-GMP sensor protein STING

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Crystallization studies of the murine c-di-GMP sensor protein STING
นักวิจัย : Su, Yi-Che , Tu, Zhi-Le , Yang, Chao-Yu , Chin, Ko-Hsin , Chuah, Mary Lay-Cheng , Liang, Zhao-Xun , Chou, Shan-Ho
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Su, Y.- C., Tu, Z.- L., Yang, C.- Y., Chin, K.- H., Chuah, M. L.- C., Liang, Z.- X., et al. (2012). Crystallization studies of the murine c-di-GMP sensor protein STING. Acta Crystallographica Section F Structural Biology and Crystallization Communications, 68(8), 906-910. , 1744-3091 , http://hdl.handle.net/10220/9184 , http://dx.doi.org/10.1107/S1744309112024372
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Acta Crystallographica Section F Structural Biology and Crystallization Communications
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The innate immune response is the first defence system against pathogenic microorganisms, and cytosolic detection of pathogen-derived DNA is believed to be one of the major mechanisms of interferon production. Recently, the mammalian ER membrane protein STING (stimulator of IFN genes; also known as MITA, ERIS, MPYS and TMEM173) has been found to be the master regulator linking the detection of cytosolic DNA to TANK-binding kinase 1 (TBK1) and its downstream transcription factor IFN regulatory factor 3 (IRF3). In addition, STING itself was soon discovered to be a direct sensor of bacterial cyclic dinucleotides such as c-di-GMP or c-di-AMP. However, structural studies of apo STING and its complexes with these cyclic dinucleotides and with other cognate binding proteins are essential in order to fully understand the roles played by STING in these crucial signalling pathways. In this manuscript, the successful crystallization of the C-terminal domain of murine STING (STING-CTD; residues 138-344) is reported. Native and SeMet-labelled crystals were obtained and diffracted to moderate resolutions of 2.39 and 2.2 Å, respectively.

บรรณานุกรม :
Su, Yi-Che , Tu, Zhi-Le , Yang, Chao-Yu , Chin, Ko-Hsin , Chuah, Mary Lay-Cheng , Liang, Zhao-Xun , Chou, Shan-Ho . (2555). Crystallization studies of the murine c-di-GMP sensor protein STING.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Su, Yi-Che , Tu, Zhi-Le , Yang, Chao-Yu , Chin, Ko-Hsin , Chuah, Mary Lay-Cheng , Liang, Zhao-Xun , Chou, Shan-Ho . 2555. "Crystallization studies of the murine c-di-GMP sensor protein STING".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Su, Yi-Che , Tu, Zhi-Le , Yang, Chao-Yu , Chin, Ko-Hsin , Chuah, Mary Lay-Cheng , Liang, Zhao-Xun , Chou, Shan-Ho . "Crystallization studies of the murine c-di-GMP sensor protein STING."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Su, Yi-Che , Tu, Zhi-Le , Yang, Chao-Yu , Chin, Ko-Hsin , Chuah, Mary Lay-Cheng , Liang, Zhao-Xun , Chou, Shan-Ho . Crystallization studies of the murine c-di-GMP sensor protein STING. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.